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Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of family members to acquired weight gain in a rare set of monozygotic...
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| Published in: | International journal of molecular sciences 2020-11, Vol.21 (21), p.8289 |
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| Main Authors: | , , , , , |
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| container_issue | 21 |
| container_start_page | 8289 |
| container_title | International journal of molecular sciences |
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| creator | Kaartinen, Mari T Arora, Mansi Heinonen, Sini Rissanen, Aila Kaprio, Jaakko Pietiläinen, Kirsi H |
| description | Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of
family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy-lean twin pairs. We report that
is the only
family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte
to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of
to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of
(ΔHeavy-Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of
in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation. |
| doi_str_mv | 10.3390/ijms21218289 |
| format | article |
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family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy-lean twin pairs. We report that
is the only
family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte
to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of
to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of
(ΔHeavy-Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of
in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21218289</identifier><identifier>PMID: 33167412</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>adipocyte size ; Adipocytes - immunology ; Adipocytes - metabolism ; Adipocytes - pathology ; Adipose Tissue - immunology ; Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adult ; Body Composition - genetics ; F131A ; Factor XIII-A ; Factor XIIIa - genetics ; Factor XIIIa - metabolism ; Female ; Gene Expression Profiling ; Genetic Association Studies ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; Humans ; Hypertrophy - genetics ; Immunity - genetics ; inflammation ; Male ; obesity ; Obesity - genetics ; Obesity - immunology ; Obesity - metabolism ; Obesity - pathology ; Protein Glutamine gamma Glutamyltransferase 2 ; Transglutaminases - genetics ; Transglutaminases - metabolism ; Transglutaminases - physiology ; Twins, Monozygotic - genetics ; weight gain</subject><ispartof>International journal of molecular sciences, 2020-11, Vol.21 (21), p.8289</ispartof><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-a7c171dd38508f5d5cf0eef6ede5ab5a4780f2eb45ae0657488a683a3160e6dd3</citedby><cites>FETCH-LOGICAL-c516t-a7c171dd38508f5d5cf0eef6ede5ab5a4780f2eb45ae0657488a683a3160e6dd3</cites><orcidid>0000-0003-2999-6502 ; 0000-0002-3716-2455 ; 0000-0001-5286-3543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663854/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663854/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33167412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaartinen, Mari T</creatorcontrib><creatorcontrib>Arora, Mansi</creatorcontrib><creatorcontrib>Heinonen, Sini</creatorcontrib><creatorcontrib>Rissanen, Aila</creatorcontrib><creatorcontrib>Kaprio, Jaakko</creatorcontrib><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><title>Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of
family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy-lean twin pairs. We report that
is the only
family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte
to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of
to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of
(ΔHeavy-Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of
in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation.</description><subject>adipocyte size</subject><subject>Adipocytes - immunology</subject><subject>Adipocytes - metabolism</subject><subject>Adipocytes - pathology</subject><subject>Adipose Tissue - immunology</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Adult</subject><subject>Body Composition - genetics</subject><subject>F131A</subject><subject>Factor XIII-A</subject><subject>Factor XIIIa - genetics</subject><subject>Factor XIIIa - metabolism</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Genetic Association Studies</subject><subject>GTP-Binding Proteins - genetics</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Hypertrophy - genetics</subject><subject>Immunity - genetics</subject><subject>inflammation</subject><subject>Male</subject><subject>obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - immunology</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Protein Glutamine gamma Glutamyltransferase 2</subject><subject>Transglutaminases - genetics</subject><subject>Transglutaminases - metabolism</subject><subject>Transglutaminases - physiology</subject><subject>Twins, Monozygotic - genetics</subject><subject>weight gain</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkc2P0zAQxS0EYpfCjTPykQMFf8ROwgGpWrG00koroXK2HHvcdZXYwXaQ8t8T2mXVvYxHfs-_8egh9J6Sz5y35Is_DplRRhvWtC_QNa0YWxMi65cX_RV6k_OREMaZaF-jK86prCvKrtG8TzrkQz8VPfigM2Ssg8X3HWRfZuwD3k7D4viKNzlH43XxMeDo8C3lG4pLxBvrx2jmAng7j5BKiuPDfIKclAx473OeAO-GYQqAf0IeY8jwFr1yus_w7vFcoV-33_c32_Xd_Y_dzeZubQSVZa1rQ2tqLW8EaZywwjgC4CRYELoTuqob4hh0ldBApKirptGy4XrZkIBc3q3Q7sy1UR_VmPyg06yi9up0EdNB6VS86UF1tpPcUFdTIysDshNOW2OpMw5qUcmF9e3MGqduAGsglKT7Z9DnSvAP6hD_qFrKZYFqAXx8BKT4e4Jc1OCzgb7XAeKUFatEy6tWLnWFPp2tJsWcE7inMZSof8mry-QX-4fLrz2Z_0fN_wKTs61a</recordid><startdate>20201105</startdate><enddate>20201105</enddate><creator>Kaartinen, Mari T</creator><creator>Arora, Mansi</creator><creator>Heinonen, Sini</creator><creator>Rissanen, Aila</creator><creator>Kaprio, Jaakko</creator><creator>Pietiläinen, Kirsi H</creator><general>MDPI</general><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2999-6502</orcidid><orcidid>https://orcid.org/0000-0002-3716-2455</orcidid><orcidid>https://orcid.org/0000-0001-5286-3543</orcidid></search><sort><creationdate>20201105</creationdate><title>Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response</title><author>Kaartinen, Mari T ; Arora, Mansi ; Heinonen, Sini ; Rissanen, Aila ; Kaprio, Jaakko ; Pietiläinen, Kirsi H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-a7c171dd38508f5d5cf0eef6ede5ab5a4780f2eb45ae0657488a683a3160e6dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>adipocyte size</topic><topic>Adipocytes - immunology</topic><topic>Adipocytes - metabolism</topic><topic>Adipocytes - pathology</topic><topic>Adipose Tissue - immunology</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Adult</topic><topic>Body Composition - genetics</topic><topic>F131A</topic><topic>Factor XIII-A</topic><topic>Factor XIIIa - genetics</topic><topic>Factor XIIIa - metabolism</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Genetic Association Studies</topic><topic>GTP-Binding Proteins - genetics</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Hypertrophy - genetics</topic><topic>Immunity - genetics</topic><topic>inflammation</topic><topic>Male</topic><topic>obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - immunology</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Protein Glutamine gamma Glutamyltransferase 2</topic><topic>Transglutaminases - genetics</topic><topic>Transglutaminases - metabolism</topic><topic>Transglutaminases - physiology</topic><topic>Twins, Monozygotic - genetics</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaartinen, Mari T</creatorcontrib><creatorcontrib>Arora, Mansi</creatorcontrib><creatorcontrib>Heinonen, Sini</creatorcontrib><creatorcontrib>Rissanen, Aila</creatorcontrib><creatorcontrib>Kaprio, Jaakko</creatorcontrib><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaartinen, Mari T</au><au>Arora, Mansi</au><au>Heinonen, Sini</au><au>Rissanen, Aila</au><au>Kaprio, Jaakko</au><au>Pietiläinen, Kirsi H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-11-05</date><risdate>2020</risdate><volume>21</volume><issue>21</issue><spage>8289</spage><pages>8289-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Transglutaminases TG2 and FXIII-A have recently been linked to adipose tissue biology and obesity, however, human studies for TG family members in adipocytes have not been conducted. In this study, we investigated the association of
family members to acquired weight gain in a rare set of monozygotic (MZ) twins discordant for body weight, i.e., heavy-lean twin pairs. We report that
is the only
family member showing significantly altered, higher expression in adipose tissue of the heavier twin. Our previous work linked adipocyte
to increased weight, body fat mass, adipocyte size, and pro-inflammatory pathways. Here, we explored further the link of
to adipocyte size in the MZ twins via a previously conducted TWA study that was further mined for genes that specifically associate to hypertrophic adipocytes. We report that differential expression of
(ΔHeavy-Lean) associated with 47 genes which were linked via gene enrichment analysis to immune response, leucocyte and neutrophil activation, as well as cytokine response and signaling. Our work brings further support to the role of
in the human adipose tissue pathology, suggesting a role in the cascade that links hypertrophic adipocytes with inflammation.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>33167412</pmid><doi>10.3390/ijms21218289</doi><orcidid>https://orcid.org/0000-0003-2999-6502</orcidid><orcidid>https://orcid.org/0000-0002-3716-2455</orcidid><orcidid>https://orcid.org/0000-0001-5286-3543</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | adipocyte size Adipocytes - immunology Adipocytes - metabolism Adipocytes - pathology Adipose Tissue - immunology Adipose Tissue - metabolism Adipose Tissue - pathology Adult Body Composition - genetics F131A Factor XIII-A Factor XIIIa - genetics Factor XIIIa - metabolism Female Gene Expression Profiling Genetic Association Studies GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans Hypertrophy - genetics Immunity - genetics inflammation Male obesity Obesity - genetics Obesity - immunology Obesity - metabolism Obesity - pathology Protein Glutamine gamma Glutamyltransferase 2 Transglutaminases - genetics Transglutaminases - metabolism Transglutaminases - physiology Twins, Monozygotic - genetics weight gain |
| title | Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response |
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