Optimizing Access to Unrelated Donors in Canada: Re-Examining the Importance of Donor Factors on Outcomes Following Hematopoietic Cell Transplantation

HLA-matched allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many patients. Unrelated HLA-matched donors are the most frequently used donor for HCT. When more than one donor transplant option is available, transplant centers can select donors based on non-HLA factors. Wi...

Full description

Saved in:
Bibliographic Details
Published in:Current oncology (Toronto) 2024-05, Vol.31 (5), p.2542-2551
Main Authors: Parmar, Gaganvir, Seftel, Matthew D, Ganz, Kathy, Blake, John, Holovati, Jelena L, Allan, David S
Format: Article
Language:English
Subjects:
allogeneic
Antithymocyte globulin
Canada
Complications and side effects
donor
hematopoietic cell transplantation
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic stem cells
Humans
outcomes
registry
selection
Transplantation
Treatment Outcome
Unrelated Donors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HLA-matched allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many patients. Unrelated HLA-matched donors are the most frequently used donor for HCT. When more than one donor transplant option is available, transplant centers can select donors based on non-HLA factors. With improved ability to prevent and treat immune complications, such as graft-versus-host disease and infections, it may be possible to proceed more often using HLA-mismatched donors, allowing greater consideration of non-HLA factors, such as donor age, CMV serostatus, and ABO blood group matching, which have demonstrated important impacts on transplant outcomes. Additional factors to consider are donor availability rates and the usage of domestic donors to optimize outcomes. A review of non-HLA factors and considerations on the selection of optimal unrelated donors for HCT are provided within this updated current context.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol31050190