Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina

• Published in: European journal of medical research 2024-12, Vol.29 (1), p.584-8
• Main Authors: Jia, Haizhen, Fan, Huajun, Zhao, Jinhe, Peng, Jun, Pan, Yunhong, Peng, Hongyan
• Format: Article
• Language: English
• Subjects: Aged; Angina, Unstable - blood; Angina, Unstable - immunology; Angina, Unstable - microbiology; Antibodies; Antibodies, Bacterial - blood; Antigens, Bacterial - immunology; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Biomarkers - blood; Cholesterol; Clinical Relevance; Cytotoxin-associated gene A; Development and progression; Enzyme-linked immunosorbent assay; Female; Genes; Helicobacter Infections - blood; Helicobacter Infections - immunology; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - immunology; Humans; Male; Medical research; Medicine, Experimental; Middle Aged; Prognosis; SYNTAX; Unstable angina; Viral antibodies
• ISSN: 0949-2321; 2047-783X; 2047-783X
• DOI: 10.1186/s40001-024-02208-5

We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA). Serum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected. Patients were followed up for 1 year for major adverse cardiac events (MACE). CagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores. CagA levels correlated positively with TC, hsCRP, and SYNTAX scores. Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients. CagA levels predicted MACE occurrence within 1 year, along with SYNTAX scores. Serum H. pylori CagA antibody positivity is associated with worse prognosis in UA patients. CagA levels correlate with lipid metabolism and inflammatory markers.