Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution

Plasma expanders are widely used for acute normovolemic hemodilution (ANH). However, existing studies have not focused on large-volume infusion with colloidal plasma expanders, and there is a lack of studies that compare the effects of different plasma expanders. The viscosity, hydrodynamic radius (...

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Bibliographic Details
Published in:Military medical research 2020-11, Vol.7 (1), p.55-55, Article 55
Main Authors: You, Guo-Xing, Li, Bing-Ting, Wang, Zhen, Wang, Quan, Wang, Ying, Zhao, Jing-Xiang, Zhao, Lian, Zhou, Hong
Format: Article
Language:English
Subjects:
Acid-base
Acute normovolemic hemodilution
Animals
Blood
Blood gas
Catheters
Chloride
Clinical medicine
Disease Models, Animal
FDA approval
Hemodilution - adverse effects
Laboratory animals
Lactate
Mortality
Patients
Physiological parameters
Physiology
Plasma
Plasma expander
Plasma Substitutes - pharmacology
Plasma Substitutes - standards
Plasma Substitutes - therapeutic use
Rats
Veins & arteries
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Summary:Plasma expanders are widely used for acute normovolemic hemodilution (ANH). However, existing studies have not focused on large-volume infusion with colloidal plasma expanders, and there is a lack of studies that compare the effects of different plasma expanders. The viscosity, hydrodynamic radius (R ) and colloid osmotic pressure (COP) of plasma expanders were determined by a cone-plate viscometer, Zetasizer and cut-off membrane, respectively. Sixty male rats were randomized into five groups with Gelofusine (Gel), Hydroxyethyl Starch 200/0.5 (HES200), Hydroxyethyl Starch 130/0.4 (HES130), Hydroxyethyl Starch 40 (HES40), and Dextran40 (Dex40), with 12 rats used in each group to build the ANH model. ANH was performed by the withdrawal of blood and simultaneous infusion of plasma expanders. Acid-base, lactate, blood gas and physiological parameters were detected. Gel had a lower intrinsic viscosity than HES200 and HES130 (P 
ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-020-00282-4