Disappearance, division, and route change of excitable reaction-diffusion waves in deformable membranes

Shapes of biomembrane in living cells are regulated by curvature-inducing proteins. However, the effects of membrane deformation on signal transductions such as chemical waves have not been researched adequately. Here, we report that membrane deformation can alter the propagation of excitable reacti...

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Bibliographic Details
Published in:Scientific reports 2023-04, Vol.13 (1), p.6207-6207, Article 6207
Main Author: Noguchi, Hiroshi
Format: Article
Language:English
Subjects:
631/57/2270
639/766/530/2803
639/766/747
Budding
Humanities and Social Sciences
Membranes
multidisciplinary
Propagation
Proteins
Science
Science (multidisciplinary)
Wave propagation
Waves
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Summary:Shapes of biomembrane in living cells are regulated by curvature-inducing proteins. However, the effects of membrane deformation on signal transductions such as chemical waves have not been researched adequately. Here, we report that membrane deformation can alter the propagation of excitable reaction-diffusion waves using state-of-the-art simulations. Reaction waves can induce large shape transformations, such as membrane budding and necking, that erase or divide the wave, depending on the curvature generated by the waves, feedback to the wave propagation, and the ratio of the reaction and deformation times. In genus-2 vesicles, wave division occurs at branching points and collided waves disappear together. We demonstrate that the occasional disappearance of the waves can alter the pathway of wave propagation. Our findings suggest that membrane deformation and reaction waves can together regulate signal transductions on biomembranes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-33376-9