Equine tendon mechanical behaviour: Prospects for repair and regeneration applications

Tendons are dense connective tissues that play an important role in the biomechanical function of the musculoskeletal system. The mechanical forces have been implicated in every aspect of tendon biology. Tendon injuries are frequently occurring and their response to treatments is often unsatisfactor...

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Bibliographic Details
Published in:Veterinary medicine and science 2023-09, Vol.9 (5), p.2053-2069
Main Author: Shojaee, Asiyeh
Format: Article
Language:English
Subjects:
Aging
biomechanics
Bioreactors
Collagen
Connective tissues
Equine
Fibroblasts
horse
Horses
Injuries
Mechanical loading
Mechanical properties
mechanobiology
Morphology
Musculoskeletal system
Rehabilitation
Review
Sliding friction
tendon
Tendons
Tensile strength
Tissue engineering
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Summary:Tendons are dense connective tissues that play an important role in the biomechanical function of the musculoskeletal system. The mechanical forces have been implicated in every aspect of tendon biology. Tendon injuries are frequently occurring and their response to treatments is often unsatisfactory. A better understanding of tendon biomechanics and mechanobiology can help develop treatment options to improve clinical outcomes. Recently, tendon tissue engineering has gained more attention as an alternative treatment due to its potential to overcome the limitations of current treatments. This review first provides a summary of tendon mechanical properties, focusing on recent findings of tendon mechanobiological responses. In the next step, we highlight the biomechanical parameters of equine energy-storing and positional tendons. The final section is devoted to how mechanical loading contributes to tenogenic differentiation using bioreactor systems. This study may help develop novel strategies for tendon injury prevention or accelerate and improve tendon healing.
ISSN:2053-1095
2053-1095
DOI:10.1002/vms3.1205