Multiparametric ultrasound assessment of axillary lymph nodes in patients with breast cancer

The presence and extent of metastatic disease in axillary lymph nodes (ALNs) in the setting of breast cancer (BC) are important factors for staging and therapy planning. The purpose of this study was to perform a multiparametric sonographic evaluation of ALNs to better differentiate between benign a...

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Bibliographic Details
Published in:Scientific reports 2024-10, Vol.14 (1), p.23072-11, Article 23072
Main Authors: Dobruch-Sobczak, Katarzyna, Szlenk, Axana, Gumowska, Magdalena, Mączewska, Joanna, Fronczewska, Katarzyna, Łukasiewicz, Ewa, Roszkowska-Purska, Katarzyna, Jakubczak, Magda
Format: Article
Language:English
Subjects:
631/67
631/67/1347
631/67/322
Adult
Aged
Aged, 80 and over
Axilla - diagnostic imaging
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Doppler effect
Elasticity Imaging Techniques - methods
Female
Humanities and Social Sciences
Humans
Lymph nodes
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymphatic Metastasis - diagnostic imaging
Lymphatic system
Metastases
Metastasis
Middle Aged
multidisciplinary
Neuroimaging
ROC Curve
Science
Science (multidisciplinary)
Statistical analysis
Ultrasonography - methods
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Summary:The presence and extent of metastatic disease in axillary lymph nodes (ALNs) in the setting of breast cancer (BC) are important factors for staging and therapy planning. The purpose of this study was to perform a multiparametric sonographic evaluation of ALNs to better differentiate between benign and metastatic nodes. Ninety-nine patients (mean age 54.1 y) with 103 BCs were included in this study, and 103 ALNs were examined sonographically. B-mode parameters, such as size in two dimensions, shape, cortical thickness and capsule outline, were obtained, followed by vascularity assessment via colour Doppler and microflow imaging and stiffness evaluation via shear wave elastography. Postoperative histopathological evaluation was the reference standard. In the statistical analysis, logistic regression and ROC analyses were conducted to search for feature patterns of both types of ALNs to evaluate the prediction qualities of the analysed variables and their combinations. For a cortex larger than 3 mm, without a circumscribed margin of the LN capsule and SWE (E max > 26 kPa), the AUC was 0.823. Multiparametric assessment, which combined conventional US, quantitative SWE and vascularity analysis, was superior to the single-parameter approach in the evaluation of ALNs.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-73376-x