Solid component tumor doubling time is a prognostic factor in non-small cell lung cancer patients

Recently, several reports investigating tumor doubling times (TDTs) in lung cancer have demonstrated that lung cancer patients with shorter TDTs have poor prognoses. Although data have shown that the solid component of a tumor is clinically more important, relationships between solid component TDTs...

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Bibliographic Details
Published in:Journal of cardiothoracic surgery 2019-03, Vol.14 (1), p.57-57, Article 57
Main Authors: Miura, Kentaro, Hamanaka, Kazutoshi, Koizumi, Tomonobu, Kawakami, Satoshi, Kobayashi, Nobutaka, Ito, Ken-Ichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cancer
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Care and treatment
CAT scans
Committees
Computed tomography
Diagnostic imaging
DNA nucleotidylexotransferase
Female
Follow-Up Studies
Growth rate
Humans
Liver cancer
Lung - pathology
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Medical imaging
Medical prognosis
Medical screening
Middle Aged
Neoplasm Staging
Non-small cell lung cancer
Non-small cell lung carcinoma
Patients
Prognosis
Retrospective Studies
Small cell lung cancer
Software
Solid component
Solid tumors
Studies
Surgeons
Surgery
Survival Analysis
Tomography
Tomography, X-Ray Computed - methods
Tumor doubling time
Tumors
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Summary:Recently, several reports investigating tumor doubling times (TDTs) in lung cancer have demonstrated that lung cancer patients with shorter TDTs have poor prognoses. Although data have shown that the solid component of a tumor is clinically more important, relationships between solid component TDTs and lung cancer prognoses remain unclear. To evaluate relationships between TDT and survival, we retrospectively evaluated 231 patients who underwent surgical resection for non-small cell lung cancer. The TDTs of whole and solid components were calculated using preoperative thin-slice chest computed tomography scans with a cut-off of 400 d between scans. Patients with short TDTs (
ISSN:1749-8090
1749-8090
DOI:10.1186/s13019-019-0879-x