A network meta-analysis assessing the effectiveness of various radical and conservative surgical approaches regarding recurrence in treating solid/multicystic ameloblastomas

Multiple treatment approaches have been undertaken to reduce the incidence of recurrence in solid/multicystic ameloblastoma (SMA), both conservative and radical. A network meta-analysis (NMA) was conducted to assess and compare the effectiveness of these various treatment approaches concurrently. Th...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.8445-8445, Article 8445
Main Authors: Hendra, Faqi Nurdiansyah, Helder, Marco N., Ruslin, Muhammad, Van Cann, Ellen M., Forouzanfar, Tymour
Format: Article
Language:English
Subjects:
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692/4028
Ameloblastoma
Ameloblastoma - surgery
Bias
Cryotherapy
Curettage
Humanities and Social Sciences
Humans
Meta-analysis
multidisciplinary
Network Meta-Analysis
Observational studies
Science
Science (multidisciplinary)
Treatment Outcome
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Summary:Multiple treatment approaches have been undertaken to reduce the incidence of recurrence in solid/multicystic ameloblastoma (SMA), both conservative and radical. A network meta-analysis (NMA) was conducted to assess and compare the effectiveness of these various treatment approaches concurrently. This study was reported based on the Preferred Reporting Items for Systematic Reviews for Network Meta-Analysis (PRISMA-NMA) statement. PubMed (MEDLINE), ScienceDirect, Scopus, and Web of Science were searched until August 10, 2021. The NMA was conducted using the STATA program. Of 1153 records identified in the search, seven observational studies with 180 patients were included. Six different treatment approaches were identified. Segmental resection ranked highest for reducing the recurrence rate with the highest SUCRA score (77.7), followed by curettage with cryotherapy (66.9) and marginal resection (49.3). Network inconsistencies and publication bias appeared to be absent. According to the Confidence in Network Meta-Analysis (CINeMa) method, the evidence's certainty was low for all comparisons due to imprecision and within-study bias. In conclusion, this study is the first NMA in the field of ameloblastoma. Segmental resection seemed to be the most effective treatment approach for minimizing recurrence in SMA patients. Nevertheless, weak certainty of evidence makes that the results must be regarded with caution.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-32190-7