Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients

To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between the serum c...

Full description

Saved in:
Bibliographic Details
Published in:International journal of ophthalmology 2014-12, Vol.7 (6), p.968-973
Main Authors: Du, Jun-Hui, Li, Xia, Li, Rong, Xu, Lin, Ma, Ran-Ran, Liu, Song-Fang, Zhang, Zhong, Sun, Hong-Zhi
Format: Article
Language:English
Subjects:
apelin-13
Clinical Research
diabetic retinopathy
vascular endothelial growth factor
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c320t-57fb6a65403291f3b8b4b3d37b9dc644152cd1d77ec15607ddd0df1d5c8f637c3
cites
container_end_page 973
container_issue 6
container_start_page 968
container_title International journal of ophthalmology
container_volume 7
creator Du, Jun-Hui
Li, Xia
Li, Rong
Xu, Lin
Ma, Ran-Ran
Liu, Song-Fang
Zhang, Zhong
Sun, Hong-Zhi
description To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy. Sixty-nine patients with T2DM were enrolled. Of the 69 patients, 16 had proliferative diabetic retinopathy (PDR group), 23 had non-PDR (NPDR group) and 30 had no retinopathy (T2DM group). Subjects' information, including demographics, medical history, and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein (CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay. Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables. Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software. Sex, age, body mass index (BMI), blood pressure, CRP, hemoglobin A1c (HbA1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2DM group (P=0.041). Differences of VEGF serum concentration in the three groups were statistically significant (P=0.007, P=0.007 and P
doi_str_mv 10.3980/j.issn.2222-3959.2014.06.10
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_be2d080d3a8c469b962a70d91bc49c29</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_be2d080d3a8c469b962a70d91bc49c29</doaj_id><sourcerecordid>1640689847</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-57fb6a65403291f3b8b4b3d37b9dc644152cd1d77ec15607ddd0df1d5c8f637c3</originalsourceid><addsrcrecordid>eNpVkUtrHDEMx01paUKar1AMvfQyE_kx9vhSKCFpA4Fe2rPxa7Lezo6ntnfLfvuYbPqIDpbRX_pJQgh9INAzNcLVto-lLD1t1jE1qJ4C4T2InsArdN6isuOjGl8__U8pZ-iylC00EwMQ4G_RGR0GDpKP5-jnzRwOpsa04DThEvJ-h80a5rh0hGFTSnLR1ODx71g3eM1pjlPIreAQsI_Ghhodzu1d0mrq5ojjgutxDZj-k5sQw1LLO_RmMnMJl8_-Av24vfl-_bW7__bl7vrzfecYhdoNcrLCiDYho4pMzI6WW-aZtMo7wTkZqPPESxkcGQRI7z34ifjBjZNg0rELdHfi-mS2es1xZ_JRJxP1UyDlB21yG2wO2gbqYQTPzOi4UFYJaiR4RazjylHVWJ9OrHVvd8G7tkc28wvoS2WJG_2QDppTCUpBA3x8BuT0ax9K1btYXJhns4S0L5oIDqJdjMuW-v7_Xn-b_LkWewQJ_5ze</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1640689847</pqid></control><display><type>article</type><title>Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients</title><source>PubMed Central</source><creator>Du, Jun-Hui ; Li, Xia ; Li, Rong ; Xu, Lin ; Ma, Ran-Ran ; Liu, Song-Fang ; Zhang, Zhong ; Sun, Hong-Zhi</creator><creatorcontrib>Du, Jun-Hui ; Li, Xia ; Li, Rong ; Xu, Lin ; Ma, Ran-Ran ; Liu, Song-Fang ; Zhang, Zhong ; Sun, Hong-Zhi</creatorcontrib><description>To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy. Sixty-nine patients with T2DM were enrolled. Of the 69 patients, 16 had proliferative diabetic retinopathy (PDR group), 23 had non-PDR (NPDR group) and 30 had no retinopathy (T2DM group). Subjects' information, including demographics, medical history, and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein (CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay. Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables. Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software. Sex, age, body mass index (BMI), blood pressure, CRP, hemoglobin A1c (HbA1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2DM group (P=0.041). Differences of VEGF serum concentration in the three groups were statistically significant (P=0.007, P=0.007 and P&lt;0.001, respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI, serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, HbA1c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13 (P=0.002), while VEGF and serum triglycerides were irrelevant. This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF.</description><identifier>ISSN: 2222-3959</identifier><identifier>EISSN: 2227-4898</identifier><identifier>DOI: 10.3980/j.issn.2222-3959.2014.06.10</identifier><identifier>PMID: 25540748</identifier><language>eng</language><publisher>China: International Journal of Ophthalmology Press</publisher><subject>apelin-13 ; Clinical Research ; diabetic retinopathy ; vascular endothelial growth factor</subject><ispartof>International journal of ophthalmology, 2014-12, Vol.7 (6), p.968-973</ispartof><rights>International Journal of Ophthalmology Press 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-57fb6a65403291f3b8b4b3d37b9dc644152cd1d77ec15607ddd0df1d5c8f637c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270990/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270990/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25540748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Jun-Hui</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Li, Rong</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Ma, Ran-Ran</creatorcontrib><creatorcontrib>Liu, Song-Fang</creatorcontrib><creatorcontrib>Zhang, Zhong</creatorcontrib><creatorcontrib>Sun, Hong-Zhi</creatorcontrib><title>Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients</title><title>International journal of ophthalmology</title><addtitle>Int J Ophthalmol</addtitle><description>To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy. Sixty-nine patients with T2DM were enrolled. Of the 69 patients, 16 had proliferative diabetic retinopathy (PDR group), 23 had non-PDR (NPDR group) and 30 had no retinopathy (T2DM group). Subjects' information, including demographics, medical history, and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein (CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay. Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables. Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software. Sex, age, body mass index (BMI), blood pressure, CRP, hemoglobin A1c (HbA1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2DM group (P=0.041). Differences of VEGF serum concentration in the three groups were statistically significant (P=0.007, P=0.007 and P&lt;0.001, respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI, serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, HbA1c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13 (P=0.002), while VEGF and serum triglycerides were irrelevant. This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF.</description><subject>apelin-13</subject><subject>Clinical Research</subject><subject>diabetic retinopathy</subject><subject>vascular endothelial growth factor</subject><issn>2222-3959</issn><issn>2227-4898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtrHDEMx01paUKar1AMvfQyE_kx9vhSKCFpA4Fe2rPxa7Lezo6ntnfLfvuYbPqIDpbRX_pJQgh9INAzNcLVto-lLD1t1jE1qJ4C4T2InsArdN6isuOjGl8__U8pZ-iylC00EwMQ4G_RGR0GDpKP5-jnzRwOpsa04DThEvJ-h80a5rh0hGFTSnLR1ODx71g3eM1pjlPIreAQsI_Ghhodzu1d0mrq5ojjgutxDZj-k5sQw1LLO_RmMnMJl8_-Av24vfl-_bW7__bl7vrzfecYhdoNcrLCiDYho4pMzI6WW-aZtMo7wTkZqPPESxkcGQRI7z34ifjBjZNg0rELdHfi-mS2es1xZ_JRJxP1UyDlB21yG2wO2gbqYQTPzOi4UFYJaiR4RazjylHVWJ9OrHVvd8G7tkc28wvoS2WJG_2QDppTCUpBA3x8BuT0ax9K1btYXJhns4S0L5oIDqJdjMuW-v7_Xn-b_LkWewQJ_5ze</recordid><startdate>20141218</startdate><enddate>20141218</enddate><creator>Du, Jun-Hui</creator><creator>Li, Xia</creator><creator>Li, Rong</creator><creator>Xu, Lin</creator><creator>Ma, Ran-Ran</creator><creator>Liu, Song-Fang</creator><creator>Zhang, Zhong</creator><creator>Sun, Hong-Zhi</creator><general>International Journal of Ophthalmology Press</general><general>Press of International Journal of Ophthalmology (IJO PRESS)</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141218</creationdate><title>Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients</title><author>Du, Jun-Hui ; Li, Xia ; Li, Rong ; Xu, Lin ; Ma, Ran-Ran ; Liu, Song-Fang ; Zhang, Zhong ; Sun, Hong-Zhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-57fb6a65403291f3b8b4b3d37b9dc644152cd1d77ec15607ddd0df1d5c8f637c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>apelin-13</topic><topic>Clinical Research</topic><topic>diabetic retinopathy</topic><topic>vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Jun-Hui</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Li, Rong</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Ma, Ran-Ran</creatorcontrib><creatorcontrib>Liu, Song-Fang</creatorcontrib><creatorcontrib>Zhang, Zhong</creatorcontrib><creatorcontrib>Sun, Hong-Zhi</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Jun-Hui</au><au>Li, Xia</au><au>Li, Rong</au><au>Xu, Lin</au><au>Ma, Ran-Ran</au><au>Liu, Song-Fang</au><au>Zhang, Zhong</au><au>Sun, Hong-Zhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients</atitle><jtitle>International journal of ophthalmology</jtitle><addtitle>Int J Ophthalmol</addtitle><date>2014-12-18</date><risdate>2014</risdate><volume>7</volume><issue>6</issue><spage>968</spage><epage>973</epage><pages>968-973</pages><issn>2222-3959</issn><eissn>2227-4898</eissn><abstract>To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy. Sixty-nine patients with T2DM were enrolled. Of the 69 patients, 16 had proliferative diabetic retinopathy (PDR group), 23 had non-PDR (NPDR group) and 30 had no retinopathy (T2DM group). Subjects' information, including demographics, medical history, and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein (CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay. Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables. Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software. Sex, age, body mass index (BMI), blood pressure, CRP, hemoglobin A1c (HbA1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2DM group (P=0.041). Differences of VEGF serum concentration in the three groups were statistically significant (P=0.007, P=0.007 and P&lt;0.001, respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI, serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, HbA1c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13 (P=0.002), while VEGF and serum triglycerides were irrelevant. This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF.</abstract><cop>China</cop><pub>International Journal of Ophthalmology Press</pub><pmid>25540748</pmid><doi>10.3980/j.issn.2222-3959.2014.06.10</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2222-3959
ispartof International journal of ophthalmology, 2014-12, Vol.7 (6), p.968-973
issn 2222-3959
2227-4898
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_be2d080d3a8c469b962a70d91bc49c29
source PubMed Central
subjects apelin-13
Clinical Research
diabetic retinopathy
vascular endothelial growth factor
title Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T19%3A06%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevation%20of%20serum%20apelin-13%20associated%20with%20proliferative%20diabetic%20retinopathy%20in%20type%202%20diabetic%20patients&rft.jtitle=International%20journal%20of%20ophthalmology&rft.au=Du,%20Jun-Hui&rft.date=2014-12-18&rft.volume=7&rft.issue=6&rft.spage=968&rft.epage=973&rft.pages=968-973&rft.issn=2222-3959&rft.eissn=2227-4898&rft_id=info:doi/10.3980/j.issn.2222-3959.2014.06.10&rft_dat=%3Cproquest_doaj_%3E1640689847%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c320t-57fb6a65403291f3b8b4b3d37b9dc644152cd1d77ec15607ddd0df1d5c8f637c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1640689847&rft_id=info:pmid/25540748&rfr_iscdi=true