Efficacy and safety of culture-expanded, mesenchymal stem/stromal cells for the treatment of knee osteoarthritis: a systematic review protocol

• Published in: Journal of orthopaedic surgery and research 2019-01, Vol.14 (1), p.34-34, Article 34
• Main Authors: Harrison-Brown, Meredith, Scholes, Corey, Hafsi, Kholoud, Marenah, Maimuna, Li, Jinjie, Hassan, Fadi, Maffulli, Nicola, Murrell, William D
• Format: Article
• Language: English
• Subjects: Animals; Case-Control Studies; Humans; Internationality; Mesenchymal Stem Cell Transplantation - adverse effects; Mesenchymal Stem Cell Transplantation - methods; Observational Studies as Topic - methods; Osteoarthritis; Osteoarthritis, Knee - diagnosis; Osteoarthritis, Knee - therapy; Randomized Controlled Trials as Topic - methods; Registries; Stem cells; Study Protocol; Surgery; Systematic Reviews as Topic; Therapeutics; Treatment Outcome
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-019-1070-8

Osteoarthritis is a progressive multifactorial condition of the musculoskeletal system with major symptoms including pain, loss of function, damage of articular cartilage and other tissues in the affected area. Knee osteoarthritis imposes major individual and social burden, especially with the cost and complexity of surgical interventions. Mesenchymal stem/stromal cells have been indicated as a treatment for degenerative musculoskeletal conditions given their capacity to differentiate into tissues of the musculoskeletal system. A systematic search will be conducted in Medline, Embase, Cochrane Library, Scopus and relevant trial databases of English, Japanese, Korean, German, French, Italian, Spanish and Portuguese language papers published or in press to June 2018, with no restrictions on publication year applied. References will be screened and assessed for eligibility by two independent reviewers as per PRISMA guidelines. Cohort, cross-sectional or case controlled studies will be included for the analysis. Data extraction will be conducted using a predefined template and quality of evidence assessed. Statistical summaries and meta-analyses will be performed as necessary. Results will be published in relevant peer-reviewed scientific journals and presented at national or international conferences by the investigators. The protocol was registered on the PROSPERO international prospective register of systematic reviews prior to commencement, CRD42018091763 .