Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues com...

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Bibliographic Details
Published in:Journal of inflammation (London, England) England), 2021-04, Vol.18 (1), p.14-14, Article 14
Main Authors: Almohammai, Asheed, Rahbarghazi, Reza, Keyhanmanesh, Rana, Rezaie, Jafar, Ahmadi, Mahdi
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Antibodies
Asthma
Biosynthesis
CD63
CD63 antigen
Comparative analysis
Esterase
Exosome biogenesis
Exosomes
Flow cytometry
Inflammation
Inflammatory cytokines
Interleukin 10
Interleukin 4
Lavage
Paracrine signalling
Physiology
Proteins
Rats
Tumor necrosis factor-α
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Summary:The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-α was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine esterase activity compared to the normal condition (p < 0.05). Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate with the inflammatory response.
ISSN:1476-9255
1476-9255
DOI:10.1186/s12950-021-00275-7