Prognostic value of cardiac biomarkers and National Early Warning Score 2 in acute dyspnoea

ObjectivePatients hospitalised with acute dyspnoea due to acute heart failure (AHF) have a grave prognosis, but the European Society of Cardiology guidelines recommend no system to risk stratify these patients. The prognostic value of combining National Early Warning Score (NEWS) 2 and established c...

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Bibliographic Details
Published in:Open heart 2022-04, Vol.9 (1), p.e001938
Main Authors: Berge, Kristian, Brynildsen, Jon, Røysland, Ragnhild, Strand, Heidi, Christensen, Geir, Høiseth, Arne Didrik, Omland, Torbjorn, Røsjø, Helge, Lyngbakken, Magnus Nakrem
Format: Article
Language:English
Subjects:
Accuracy
Aged
Biomarkers
Cardiovascular disease
Chronic obstructive pulmonary disease
Clinical deterioration
Clinical medicine
Dyspnea
Dyspnea - diagnosis
Dyspnea - etiology
Early Warning Score
Electronic records
Female
Heart attacks
HEART FAILURE
Heart Failure - diagnosis
Heart Failure and Cardiomyopathies
Heart Failure, Diastolic
Heart Failure, Systolic
Hospitalization
Hospitals
Humans
Medical prognosis
Mortality
Peptides
Physicians
Prognosis
Troponin T
Variables
Vital signs
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Summary:ObjectivePatients hospitalised with acute dyspnoea due to acute heart failure (AHF) have a grave prognosis, but the European Society of Cardiology guidelines recommend no system to risk stratify these patients. The prognostic value of combining National Early Warning Score (NEWS) 2 and established cardiac biomarkers is not known.MethodsWe measured high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and calculated NEWS2 in 314 patients with acute dyspnoea within 24 hours of hospitalisation. Their prognostic merits were assessed in the total cohort and for the subgroup with AHF separately.ResultsThe median age was 73 (quartile (Q) 1–3, 63–81) years, 48% were women and 143 patients (46%) were hospitalised with AHF. The 114 patients (36%) who died during follow-up (median 823 days, Q1–3, 471–998) had higher concentrations of hs-cTnT (62 vs 33 ng/L, p
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2021-001938