Plasma Uric Acid, Lactate, and Osmolality in Colorectal Cancer

A complex evaluation of colorectal cancer (CRC) in relation to screening, diagnosis, stage determination, prognosis, and treatment requires valuable biomarkers. The aim of this study was to measure selected biomarkers—uric acid (UA), lactate, Na+, Cl−, and osmolality—in CRC patients and to assess th...

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Published in:Applied sciences 2024-07, Vol.14 (13), p.5630
Main Authors: Kiselova-Kaneva, Yoana, Vankova, Deyana, Kolev, Nikola, Kalinov, Turgay, Zlatarov, Alexandar, Komosinska-Vassev, Katarzyna, Olczyk, Pawel, Yaneva, Galina, Slavova, Svetla, Ivanov, Krasimir, Ivanova, Diana
Format: Article
Language:English
Subjects:
Adipocytes
Biomarkers
Body fat
Colorectal cancer
Electrolytes
Gender
hyponatremia
lactate
Medical prognosis
Metabolism
Obesity
osmolality
Plasma
Rheumatism
Statistical analysis
Uric acid
Womens health
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Summary:A complex evaluation of colorectal cancer (CRC) in relation to screening, diagnosis, stage determination, prognosis, and treatment requires valuable biomarkers. The aim of this study was to measure selected biomarkers—uric acid (UA), lactate, Na+, Cl−, and osmolality—in CRC patients and to assess their diagnostic value to distinguish between CRC and healthy controls. Plasma lactate (2.21 ± 0.11 vs. 2.88 ± 0.19, p < 0.01), Na+ (130.79 ± 0.42 vs. 133.23 ± 0.25, p < 0.001), Cl− (102.59 ± 0.45 vs. 103.94 ± 0.23, p < 0.01), and osmolality (266.44 ± 0.86 vs. 271.72 ± 0.62, p < 0.001) were found to be significantly lower in CRC patients as compared to the healthy controls group. Among them, with satisfactory diagnostic potential, were plasma Na+ concentrations and osmolality (AUCNa+ = 0.752, p < 0.0001; AUCosmolality = 0.757, p < 0.05), respectively. UA concentrations were detected at higher concentrations in CRC patients (333.67 ± 13.05 vs. 295.88 ± 13.78, p < 0.05). The results of this study contribute to the elucidation of molecular mechanisms of CRC pathogenesis and the role of studied metabolic parameters in this process. Plasma uric acid, lactate, and osmolality parameters can be used for screening and monitoring colorectal cancer. Further studies are required to elucidate the molecular mechanisms of their action in cancer development. The action of circulating plasma lactate may be different from those locally produced in the tumor microenvironment.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14135630