Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs

The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionalities. Demonstrating the role of diet may be complex as most human studies are cross-section...

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Bibliographic Details
Published in:Animal microbiome 2024-11, Vol.6 (1), p.69-16, Article 69
Main Authors: Rhimi, Soufien, Jablaoui, Amin, Hernandez, Juan, Mariaule, Vincent, Akermi, Nizar, Méric, Tristan, Mkaouar, Héla, Wysocka, Magdalena, Lesner, Adam, Borgi, Mohamed Ali, Maguin, Emmanuelle, Rhimi, Moez
Format: Article
Language:English
Subjects:
Animal biology
Biochemistry, Molecular Biology
Diet intervention
Dog
Gut microbiota
Host response
Industrial diet
Life Sciences
Microbiology and Parasitology
Semi-stray dog
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Summary:The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionalities. Demonstrating the role of diet may be complex as most human studies are cross-sectional and dietary intervention is often accompanied by hygienic changes. The objective of the present study was to investigate the impact of an industrial diet on the modulation of the microbiota and targeted functionalities using a canine "natural" model. We carried out a controlled dietary trial in a cohort of Tunisian semi-stray dogs. We made a transition from a natural diet to an industrial kibble diet and monitored the composition of the fecal microbiota, the concentration of short-chain fatty acids (SCFA) and bile acids (BAs), and protease activities. We demonstrated that dietary change significantly decreased fecal primary bile acids levels and protease activities. Interestingly, correlation analyses demonstrated that variation of specific microbial genera were associated with modulated physiological parameters. Our study reveals that an industrial diet induces beneficial changes in microbial composition and functions characterised by increased diversity, synthesis of SCFA and secondary bile acids production, stressing the key role of the diet-microbiota-dog crosstalk.
ISSN:2524-4671
2524-4671
DOI:10.1186/s42523-024-00357-w