Clinical Evidence on the Potential Beneficial Effects of Probiotics and Prebiotics in Cardiovascular Disease

• Published in: International journal of molecular sciences 2022-12, Vol.23 (24), p.15898
• Main Authors: Pavlidou, Eleni, Fasoulas, Aristeidis, Mantzorou, Maria, Giaginis, Constantinos
• Format: Article
• Language: English
• Subjects: Angina pectoris; Bacteria; Bacteria - metabolism; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - prevention & control; clinical studies; Coronary artery disease; Digestive system; Enteral nutrition; Food; Gastrointestinal system; Gastrointestinal tract; Gastrointestinal Tract - microbiology; gut microbiota; Heart diseases; Heart failure; Humans; Hypertension; Immune system; Inflammation; Insulin; Insulin resistance; Intestinal microflora; Intestines - microbiology; Literature reviews; Metabolism; Microbiomes; Microbiota; Microorganisms; Nutrients; Nutrition; Oxidative stress; Prebiotics; Probiotics; Probiotics - pharmacology; Probiotics - therapeutic use; Protozoa; Review; Risk analysis; Risk factors; Stroke; Sugar
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms232415898

The 'gut microbiome'-the hundreds of trillions of bacteria in the human gastrointestinal tract-serves several functions. The gut microbiome includes all the microorganisms, bacteria, viruses, protozoa, and fungi in the gastrointestinal tract and their genetic material. It helps digest indigestible foods and produces nutrients. Through the metabolism of sugars and proteins, it helps the intestinal barrier, the immune system, and metabolism. Some bacteria, such as those in the gut microbiome, cause disease, but others are essential to our health. These "good" microbes protect us from pathogens. Numerous studies have linked an unhealthy gut microbiome to obesity, insulin resistance, depression, and cardiometabolic risk factors. To maximize probiotic benefits in each case, knowledge of probiotic bacterial strains and how to consume them should be increased. This study aims to examine the benefits of probiotic and prebiotic organisms on cardiovascular health, specifically on heart disease, coronary heart disease, stroke, and hypertension. To complete the research, a literature review was conducted by gathering clinical studies and data. The clinical evidence demonstrates the beneficial effect of probiotics and prebiotic microorganisms on the gut microbiome, which has multiple benefits for overall health and especially for cardiovascular diseases.