Effects of radiation therapy on tumor microenvironment: an updated review

Cancer is a major threat to human health and causes death worldwide. Research on the role of radiotherapy (RT) in the treatment of cancer is progressing; however, RT not only causes fatal DNA damage to tumor cells, but also affects the interactions between tumor cells and different components of the...

Full description

Saved in:
Bibliographic Details
Published in:Chinese medical journal 2023-12, Vol.136 (23), p.2802-2811
Main Authors: Zhang, Zewen, Peng, Yuanhao, Peng, Xin, Xiao, Desheng, Shi, Ying, Tao, Yongguang
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Antigen presentation
Cancer therapies
Cell death
Cell growth
Chemokines
Cytokines
Endoplasmic reticulum
Fibroblasts
Gamma rays
Immune system
Immunotherapy
Kinases
Ligands
Lymphocytes
Metastasis
Proteins
Radiation therapy
Review
Senescence
T cell receptors
Tumor necrosis factor-TNF
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer is a major threat to human health and causes death worldwide. Research on the role of radiotherapy (RT) in the treatment of cancer is progressing; however, RT not only causes fatal DNA damage to tumor cells, but also affects the interactions between tumor cells and different components of the tumor microenvironment (TME), including immune cells, fibroblasts, macrophages, extracellular matrix, and some soluble products. Some cancer cells can survive radiation and have shown strong resistance to radiation through interaction with the TME. Currently, the complex relationships between the tumor cells and cellular components that play major roles in various TMEs are poorly understood. This review explores the relationship between RT and cell-cell communication in the TME from the perspective of immunity and hypoxia and aims to identify new RT biomarkers and treatment methods in lung cancer to improve the current status of unstable RT effect and provide a theoretical basis for further lung cancer RT sensitization research in the future.
ISSN:2542-5641
0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002535