Medium-Chain Fatty Acids and Breast Cancer Risk by Receptor and Pathological Subtypes

• Published in: Nutrients 2022-12, Vol.14 (24), p.5351
• Main Authors: Roopashree, Padmanabha Ganeshkodi, Shetty, Shilpa S, Shetty, Vijith Vittal, Nalilu, Suchetha Kumari
• Format: Article
• Language: English
• Subjects: Age; Blood vessels; Body mass index; Breast cancer; Breast Neoplasms; Caprylates; caprylic acid; Chemical properties; Cholesterol; Colorectal cancer; Creatinine; Diet; Dietary fat; ErbB-2 protein; Esters; Family medical history; Fatty acid composition; Fatty acid methyl esters; Fatty acids; Fatty Acids - analysis; Female; Gas chromatography; Health aspects; Health risks; Hexanoic acid; High density lipoprotein; Humans; Lauric acid; Lauric Acids; Lipoproteins; medium-chain fatty acids; Octanoic acid; Physiological aspects; Population; Portal vein; Risk; Risk factors; Saturated fatty acids; Statistical analysis; Therapeutic applications
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14245351

Medium-chain fatty acids contain 6-12 carbon atoms and are absorbed directly into the blood vessels, proceeding to the portal vein and, finally, to the liver, where they are immediately utilized for energy. We aimed to determine the medium-chain fatty acid levels in women with and without breast cancer. A total of 200 women (100 breast cancer subjects and 100 control subjects) were recruited for the study as per the inclusion and exclusion criteria. Blood samples were collected for biochemical estimations. Fatty acid methyl esters were isolated, and medium-chain fatty acid levels in plasma were analyzed using gas chromatography (GC-FID). Statistical analysis was performed using SPSS 20.0 software; ≤ 0.05 was considered statistically significant. The fatty acid analysis revealed a significant decrease in the levels of caprylic acid (C:8) and lauric acid (C:12) and a significant increase in the level of capric acid (C:10) in the breast cancer subjects when compared to the control group. The level of caproic acid (C:6) was not significantly increased in the breast cancer subjects. In particular, the HER2- and ER-positive breast cancer subjects showed a decrease in their caprylic acid and lauric acid levels compared to other receptors. The results of the current study imply that lower levels of caprylic and lauric acid may be associated with a higher risk of breast cancer. The relevance of medium-chain fatty acids for preventive and therapeutic interventions will be amplified by further research on the possibility that alteration in a patient's medium-chain fatty acid composition may mechanistically contribute to disease progression or breast cancer risk.