Risk factors of vertebral re-fracture after PVP or PKP for osteoporotic vertebral compression fractures, especially in Eastern Asia: a systematic review and meta-analysis

Percutaneous vertebroplasty (PVP) and kyphoplasty (PKP) have been widely used to treat osteoporotic vertebral compression fractures (OVCF), but the risk of vertebral re-fracture after PVP/PKP remains controversial. This study aims to investigate the incidence and risk factors of vertebral re-fractur...

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Published in:Journal of orthopaedic surgery and research 2022-03, Vol.17 (1), p.161-161, Article 161
Main Authors: Dai, Chuanqiang, Liang, Gang, Zhang, Youshu, Dong, Yao, Zhou, Xiaodan
Format: Article
Language:English
Subjects:
Fractures
Medical research
Medicine, Experimental
Meta-analysis
Osteoporosis
Osteoporotic vertebral compression fracture
Percutaneous kyphoplasty
Percutaneous vertebroplasty
Povidone
Refracture
Risk factors
Systematic Review
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Summary:Percutaneous vertebroplasty (PVP) and kyphoplasty (PKP) have been widely used to treat osteoporotic vertebral compression fractures (OVCF), but the risk of vertebral re-fracture after PVP/PKP remains controversial. This study aims to investigate the incidence and risk factors of vertebral re-fracture after PVP/PKP. Relevant literatures published up to November 2021 were collected from PubMed, Embase and Web of Science. A meta-analysis was performed to extract data associated with risk factors of SVCF following the PRISMA guidelines. Also, pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI) was calculated. A total of 23 studies, encompassing 9372 patients with OVCF, met the inclusion criteria. 1255 patients (13.39%) suffered re-fracture after PVP/PKP surgery. A total of 22 studies were from Eastern Asia and only 1 study was from Europe. Female sex (OR = 1.34, 95%CI 1.09-1.64, P = 0.006), older age (WMD = 2.04, 95%CI 0.84-3.24, P = 0.001), lower bone mineral density (BMD, WMD = - 0.38, 95%CI - 0.49-0.26, P 
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-022-03038-z