HIV-1 Non-Group M Strains and ART

To eliminate HIV infection, there are several elements to take into account to limit transmission and break viral replication, such as epidemiological, preventive or therapeutic management. The UNAIDS goals of screening, treatment and efficacy should allow for this elimination if properly followed....

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Bibliographic Details
Published in:Viruses 2023-03, Vol.15 (3), p.780
Main Authors: Alessandri-Gradt, Elodie, Moisan, Alice, Plantier, Jean-Christophe
Format: Article
Language:English
Subjects:
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
Care and treatment
Disease management
Distribution
elimination
Epidemiology
Genetic aspects
Genetic divergence
Genetic diversity
Genetic Drift
genetic variants
Genomes
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV infection
HIV Infections - diagnosis
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Seropositivity
HIV-1
HIV-1 - genetics
Human immunodeficiency virus
Humans
Infections
Monkeys & apes
Mutation
Pandemics
Patient outcomes
Polymorphism
Review
Serology
Vigilance
Viral Load
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Summary:To eliminate HIV infection, there are several elements to take into account to limit transmission and break viral replication, such as epidemiological, preventive or therapeutic management. The UNAIDS goals of screening, treatment and efficacy should allow for this elimination if properly followed. For some infections, the difficulty is linked to the strong genetic divergence of the viruses, which can impact the virological and therapeutic management of patients. To completely eliminate HIV by 2030, we must therefore also be able to act on these atypical variants (HIV-1 non-group M) which are distinct from the group M pandemic viruses. While this diversity has had an impact on the efficacy of antiretroviral treatment in the past, recent data show that there is real hope of eliminating these forms, while maintaining vigilance and constant surveillance, so as not to allow more divergent and resistant forms to emerge. The aim of this work is therefore to share an update on the current knowledge on epidemiology, diagnosis and antiretroviral agent efficacy of HIV-1 non-M variants.
ISSN:1999-4915
1999-4915
DOI:10.3390/v15030780