The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

S100A6, also known as calcyclin, is a low-molecular-weight Ca -binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as m...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-07, Vol.13 (7), p.1139
Main Authors: Yang, Fengguang, Ma, Jinglin, Zhu, Daxue, Wang, Zhaoheng, Li, Yanhu, He, Xuegang, Zhang, Guangzhi, Kang, Xuewen
Format: Article
Language:English
Subjects:
Alzheimer's disease
Arthritis
Binding proteins
Biomarkers
Bone cancer
Calcium-binding protein
Cardiovascular diseases
Cardiovascular system
Care and treatment
Cell cycle
Cell differentiation
Cell proliferation
China
Colorectal cancer
Cytoskeleton
Diseases
Endometriosis
Gastric cancer
Health aspects
Homeopathy
Leukemia
Liver cancer
Lymphatic system
Mammalian cells
Materia medica and therapeutics
Medical prognosis
Medical research
Medicine, Experimental
Melanoma
Metastasis
Molecular modelling
myocardial infarction
Nervous system
Nervous system diseases
Osteoarthritis
Pancreatic cancer
Pathogenesis
Physiological aspects
Proteins
Review
S100A6
S100A6 protein
Therapeutic targets
Therapeutics
Thyroid gland
tumor
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:S100A6, also known as calcyclin, is a low-molecular-weight Ca -binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13071139