The Antimicrobial Resistance (AMR) Rates of Uropathogens in a Rural Western African Area-A Retrospective Single-Center Study from Kpando, Ghana

• Published in: Antibiotics (Basel) 2022-12, Vol.11 (12), p.1808
• Main Authors: Deininger, Susanne, Gründler, Therese, Deininger, Sebastian Hubertus Markus, Lütcke, Karina, Lütcke, Harry, Agbesi, James, Ladzaka, Williams, Gyamfi, Eric, Wichlas, Florian, Hofmann, Valeska, Erne, Eva, Törzsök, Peter, Lusuardi, Lukas, Kern, Jan Marco, Deininger, Christian
• Format: Article
• Language: English
• Subjects: Antibiotics; Antimicrobial agents; Antimicrobial resistance; Bacteria; bacterial resistance rates; Cell culture; Citrobacter; Documentation; Drug resistance; Drug resistance in microorganisms; E coli; Epithelial cells; Epithelium; Escherichia coli; Hospitals; International cooperation; Klebsiella; Laboratories; low-income country; Microbiology; Microscopy; Morphology; Mutation; Pathogens; Penicillin; Pneumonia; Public health; R&D; Research & development; Rural areas; Salmonella; Statistical analysis; Tetracycline; Tetracyclines; Urine; uropathogen infection
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics11121808

Little is known about the antimicrobial resistance (AMR) status of uropathogens in Western Africa. We performed a retrospective evaluation of urine cultures collected from the rural Margret Marquart Catholic Hospital, Kpando, Ghana during the time period from October 2019−December 2021. Urine samples from 348 patients (median age 40 years, 52.6% male) were examined. Of these, 125 (35.9%) showed either fungal or bacterial growth, including Escherichia coli in 48 (38.4%), Candida species (spp.) in 29 (23.2%), Klebsiella spp. in 27 (21.6%), Proteus spp. in 12 (9.6%), Citrobacter spp. in 10 (8.0%), Salmonella spp. in 4 (3.2%), Staphylococcus spp. in 3 (2.4%), and Pseudomonas spp. in 2 (1.6%) cases. Two bacterial spp. were detected in 7 samples (5.6%). Antibiotic susceptibility testing showed resistance to a mean 8.6 out of 11 tested antibiotics per patient. Significant predictors (p < 0.05) of bacterial growth were age (OR 1.03), female sex (OR 3.84), and the number of pus cells (OR 1.05) and epithelial cells (OR 1.07) in urine microscopy. We observed an alarmingly high AMR rate among the uropathogens detected, even to reserve antibiotics. A similar resistance profile can be expected in West African patients living in high-income countries. These observations warrant the implementation of restrictive antibiotic protocols, together with the expansion of urine culture testing capacities, improvement of documentation and reporting of AMR rates, and continued research and development of new antibiotic therapies in order to stem the progression of AMR in this West African region.