An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure

This study sought to evaluate the association between newly-developed significant hypercholesterolemia within one year following living donor liver transplantation (LDLT) and long term outcomes in light of cardiovascular events and graft failure. From October 2003 to July 2017, 877 LDLT recipients w...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.959-959, Article 959
Main Authors: Park, Jungchan, Lee, Seung-Hwa, Han, Sangbin, Oh, Ah Ran, Lee, Suk-Koo, Choi, Gyu-Seong, Park, Myung Soo, Carriere, Keumhee, Ahn, Joonghyun, Kim, Gaab Soo
Format: Article
Language:English
Subjects:
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Cardiovascular disease
Cholesterol
Confidence intervals
Graft rejection
Grafts
Humanities and Social Sciences
Hypercholesterolemia
Liver diseases
Liver transplantation
Liver transplants
Medicine
Mortality
multidisciplinary
Myocardial infarction
Observational studies
Science
Science (multidisciplinary)
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Summary:This study sought to evaluate the association between newly-developed significant hypercholesterolemia within one year following living donor liver transplantation (LDLT) and long term outcomes in light of cardiovascular events and graft failure. From October 2003 to July 2017, 877 LDLT recipients were stratified according to development of significant hypercholesterolemia within one year following LDLT. The primary outcome was occurrence of a major adverse cardiac event (MACE), defined as a composite of cardiac death, myocardial infarction, and coronary revascularization after LDLT. The incidence of graft failure, defined as all-cause death or retransplantation, was also compared. A total of 113 (12.9%) recipients developed significant hypercholesterolemia within one year. The differences in incidences of cardiac related events and graft related events began emerging significantly higher in the hypercholesterolemia group after 24 months and 60 months since the LDLT, respectively. After adjustment using the inverse probability of weighting, the hazard ratio (HR) for MACE was 2.77 (95% confidence interval (CI) 1.16–6.61; p  = 0.02), while that for graft failure was 3.76 (95% CI 1.97–7.17, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79673-5