Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology

Organ-on-a-chip (OoC) is an exponential technology with the potential to revolutionize disease, toxicology research, and drug discovery. Recent advances in OoC could be utilized for drug screening in disease models to evaluate the efficacy of new therapies and support new tools for the understanding...

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Bibliographic Details
Published in:Micromachines (Basel) 2021-02, Vol.12 (2), p.215
Main Authors: Hwang, Seong-Hye, Lee, Sangchul, Park, Jee Yoon, Jeon, Jessie Sungyun, Cho, Young-Jae, Kim, Sejoong
Format: Article
Language:English
Subjects:
Cancer
cancer models
Cancer therapies
Cell culture
drug efficacy
drug testing
Genetic engineering
Hydrogels
Kidneys
Lungs
Medical research
microfluidics technologies
organ-on-a-chip
Physiology
Review
Stem cells
Toxicology
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Summary:Organ-on-a-chip (OoC) is an exponential technology with the potential to revolutionize disease, toxicology research, and drug discovery. Recent advances in OoC could be utilized for drug screening in disease models to evaluate the efficacy of new therapies and support new tools for the understanding of disease mechanisms. Rigorous validation of this technology is required to determine whether OoC models may represent human-relevant physiology and predict clinical outcomes in target disease models. Achievements in the OoC field could reveal exciting new avenues for drug development and discovery. This review attempts to highlight the benefits of OoC as per our understanding of the cellular and molecular pathways in lung and kidney cancer models, and discusses the challenges in evaluating drug efficacy.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi12020215