Castleman disease mimicked pancreatic carcinoma: report of two cases

Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old...

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Bibliographic Details
Published in:World journal of surgical oncology 2012-07, Vol.10 (1), p.154-154, Article 154
Main Authors: Guo, Hua, Shen, Yan, Wang, Wei-Lin, Zhang, Min, Li, Hong, Wu, Ying-Sheng, Yan, Sheng, Xu, Xiao, Wu, Jian, Zheng, Shu-Sen
Format: Article
Language:English
Subjects:
Abdomen
Adult
Autoimmune diseases
Biomarkers
Care and treatment
Case Report
Case studies
Castleman disease
Castleman Disease - diagnosis
Chemotherapy
Consent
CT imaging
Cytokines
Diagnosis
Diagnosis, Differential
Diagnostic imaging
Disease
Family medical history
Female
Herpes viruses
HIV
Hospitals
Human immunodeficiency virus
Humans
Hyaline-vascular type
Lymphoproliferative disorders
Male
Medical treatment
Middle Aged
Morbidity
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Peripancreatic tumor
Plasma
Public health
Radiation therapy
Surgery
Tumors
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Summary:Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old woman were detected to have a pancreatic mass in the routine medical examinations. Both of them were asymptomatic. The computed tomography and ultrasonographic examination revealed a mild enhancing solitary mass at the pancreatic head/neck. No definite preoperative diagnosis was established and Whipple operations were originally planned. The intraoperative frozen section diagnosis of both patients revealed lymphoproliferation. Then the local excisions of mass were performed. Histological examination revealed features of CD of hyaline-vascular type. No recurrence was found during the follow-up period. CD should be included in the differential diagnosis of pancreatic tumors. Local excision is a suitable surgical choice.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-10-154