PRP in OA knee - update, current confusions and future options

Positive results have been uniformly observed by various researchers for platelet-rich plasma (PRP) in early osteoarthritis (OA) knee in the past few years. PRP has clearly demonstrated its supremacy in comparison to hyaluronic acid (HA) and placebo in various clinical trials and is undoubtedly the...

Full description

Saved in:
Bibliographic Details
Published in:SICOT-J 2017, Vol.3, p.27-27
Main Authors: Dhillon, Mandeep S, Patel, Sandeep, John, Rakesh
Format: Article
Language:English
Subjects:
Acids
Analgesics
Apoptosis
Arthritis
Blood platelets
Classification
Early OA knee
Gene expression
Growth factors
Hyaluronic acid
Hydrogels
Knee
Pain
Platelet-rich plasma
Review
Sports injuries
Tumor necrosis factor-TNF
Ultrasonic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Positive results have been uniformly observed by various researchers for platelet-rich plasma (PRP) in early osteoarthritis (OA) knee in the past few years. PRP has clearly demonstrated its supremacy in comparison to hyaluronic acid (HA) and placebo in various clinical trials and is undoubtedly the best option available for symptomatic treatment in early OA. The release of growth factors from PRP occurs immediately and lasts for around three weeks and the clinical effect tends to wane down by the end of the year. Prolonged and sustained release of growth factors from platelets could possibly help in much better biological healing and sustained clinical effects. PRP in combination with biocompatible carriers could be one way of achieving this. Gelatin hydrogel PRP and chitosan PRP seem to be promising based on early in vitro studies and animal studies. PRP in combination with hyaluronic acid also seems to be additive. This article intends to discuss the present status of the PRP, confusions surrounding its use, upcoming trends and ideas for improvising PRP for use early OA knees based on available evidence.
ISSN:2426-8887
2426-8887
DOI:10.1051/sicotj/2017004