Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

• Published in: Brazilian journal of biology 2023, Vol.83, p.e272512-5
• Main Authors: Sales, C A, Pinto-Silva, M C F, Bardález-Rivera, J G, Abreu-Alberio, C A, Sena, L W P, Vieira, J L F
• Format: Article
• Language: English
• Subjects: Alkaline phosphatase; Alkaline Phosphatase - metabolism; Alkaline Phosphatase - pharmacology; Anticoagulants; BIOLOGY; Blood; Brazil; Catalase; Chemotherapy; Drug dosages; Enzymes; Glutathione; Hospitals; Humans; Infectious diseases; Liver; liver markers and levofloxacin; Male; Multidrug resistance; Multidrug resistant organisms; multidrug-resistant tuberculosis; oxidation enzymes; Oxidation resistance; Oxidative Stress; Patients; Phosphatase; Spectrophotometry; Substance abuse treatment; Tuberculosis; Tuberculosis, Multidrug-Resistant - metabolism; Womens health
• ISSN: 1519-6984; 1678-4375; 1678-4375
• DOI: 10.1590/1519-6984.272512

This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p