Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, China

Given that a substantial proportion of the subgroup of COVID-19 patients that face a severe disease course are younger than 60 years, it is critical to understand the disease-specific characteristics of young COVID-19 patients. Risk factors for a severe disease course for young COVID-19 patients and...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.7857-10, Article 7857
Main Authors: Cheng, Weiting, Hornung, Roman, Xu, Kai, Yang, Cai hong, Li, Jian
Format: Article
Language:English
Subjects:
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692/699
Adolescent
Adult
Age
Amyloid
Area Under Curve
C-reactive protein
China - epidemiology
Complement C3 - analysis
Complement component C3
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - immunology
Female
Humanities and Social Sciences
Humans
Influence
L-Lactate dehydrogenase
Lactic acid
Lymphocytes
Male
Medical records
Middle Aged
Models, Statistical
multidisciplinary
Multivariate Analysis
Nonlinear Dynamics
Patients
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Severity of Illness Index
Young Adult
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Summary:Given that a substantial proportion of the subgroup of COVID-19 patients that face a severe disease course are younger than 60 years, it is critical to understand the disease-specific characteristics of young COVID-19 patients. Risk factors for a severe disease course for young COVID-19 patients and possible non-linear influences remain unknown. Data were analyzed from COVID-19 patients with clinical outcome in a single hospital in Wuhan, China, collected retrospectively from Jan 24th to Mar 27th. Clinical, demographic, treatment and laboratory data were collected from patients' medical records. Uni- and multivariable analysis using logistic regression and random forest, with the latter allowing the study of non-linear influences, were performed to investigate the clinical characteristics of a severe disease course. A total of 762 young patients (median age 47 years, interquartile range [IQR] 38–55, range 18–60; 55.9% female) were included, as well as 714 elderly patients as a comparison group. Among the young patients, 362 (47.5%) had a severe/critical disease course and the mean age was statistically significantly higher in the severe subgroup than in the mild subgroup (59.3 vs. 56.0, Student's t-test: p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-82810-3