Commentary: Roles of the Cannabinoid System in the Basal Ganglia in Parkinson's Disease

Additionally, the relevance of the TRPV1 receptor as a new therapeutic target against LID is still not clearly understood and the experimental results, including the interaction with CB1, also remain controversial. [...]the existence of heterodimeric phenomena between CB1 and D2 receptors should als...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2022-05, Vol.16, p.897930-897930
Main Authors: Oikonomou, Panteleimon, Jost, Wolfgang H
Format: Article
Language:English
Subjects:
Antioxidants
Basal ganglia
Cannabidiol
Cannabinoid CB1 receptors
Cannabinoid CB2 receptors
Cannabinoids
Capsaicin receptors
CB1 receptors
CB2 receptors
Cell culture
Cellular Neuroscience
Clinical trials
Conflicts of interest
Dopamine
Dyskinesia
Endocannabinoid system
Enzymes
Glial cells
Inflammation
Metabolism
Movement disorders
Neostriatum
Neurodegenerative diseases
Neuronal-glial interactions
Neuroplasticity
Neuroprotection
Parkinson's disease
Parkinson's disease (PD)
Pathophysiology
RCT - randomized controlled trial
Roles
Synaptic plasticity
Therapeutic targets
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Summary:Additionally, the relevance of the TRPV1 receptor as a new therapeutic target against LID is still not clearly understood and the experimental results, including the interaction with CB1, also remain controversial. [...]the existence of heterodimeric phenomena between CB1 and D2 receptors should also be taken into consideration during the interpretation of an experimental study in this field. CB2 receptors are mainly distributed in brain glial cells and neural precursor cells, and less in nerve cells. [...]the neuroprotective effect could be promoted by an inflammatory modulation mechanism with fewer central nervous side effects. [...]basal research is needed to clarify the effect of the other cannabinoid receptors, e.g., TRPV-1 and GPR55 on neural cells, and the concept of antioxidant properties of different cannabinoids, which could be receptor-independent. [...]the authors supported the thesis that eCB-mediated restoration of cortical striatal synaptic plasticity through retrograde messenger function contributes to the improvement in motor symptoms in PD (Wang et al., 2022).
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2022.897930