Functional Heterogeneity of Bone Marrow Mesenchymal Stem Cell Subpopulations in Physiology and Pathology

Bone marrow mesenchymal stem cells (BMSCs) are multi-potent cell populations and are capable of maintaining bone and body homeostasis. The stemness and potential therapeutic effect of BMSCs have been explored extensively in recent years. However, diverse cell surface antigens and complex gene expres...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11928
Main Authors: Ning, Kaiting, Yang, Baoqiang, Chen, Meng, Man, Guigui, Liu, Shuaiting, Wang, Dong-En, Xu, Huiyun
Format: Article
Language:English
Subjects:
Adipocytes
Antigens
Antigens, Surface - metabolism
Bone and Bones
Bone marrow
Bone Marrow Cells
Cartilage
Cell surface
Flow cytometry
functional heterogeneity of BMSCs
Gene expression
Heterogeneity
Homeostasis
Hypoxia
Medical innovations
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
pathological-related BMSC subpopulation
Pathology
physiological status
Physiology
Populations
Public health
Review
Stem cells
Surface antigens
Sutures
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Summary:Bone marrow mesenchymal stem cells (BMSCs) are multi-potent cell populations and are capable of maintaining bone and body homeostasis. The stemness and potential therapeutic effect of BMSCs have been explored extensively in recent years. However, diverse cell surface antigens and complex gene expression of BMSCs have indicated that BMSCs represent heterogeneous populations, and the natural characteristics of BMSCs make it difficult to identify the specific subpopulations in pathological processes which are often obscured by bulk analysis of the total BMSCs. Meanwhile, the therapeutic effect of total BMSCs is often less effective partly due to their heterogeneity. Therefore, understanding the functional heterogeneity of the BMSC subpopulations under different physiological and pathological conditions could have major ramifications for global health. Here, we summarize the recent progress of functional heterogeneity of BMSC subpopulations in physiology and pathology. Targeting tissue-resident single BMSC subpopulation offers a potentially innovative therapeutic strategy and improves BMSC effectiveness in clinical application.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911928