Progressive Encephalomyelitis With Rigidity and Myoclonus With Thymoma: A Case Report and Literature Review

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is part of the variant type of the Stiff Person Syndrome (SPS) and is a rare neurological disease. We report here a patient with PERM who had thymoma and was positive for anti-glutamic acid decarboxylase (anti-GAD) antibodies. Her symp...

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Bibliographic Details
Published in:Frontiers in neurology 2020-09, Vol.11
Main Authors: Su, Yana, Cui, Li, Zhu, Mingqin, Liang, Yixuan, Zhang, Ying
Format: Article
Language:English
Subjects:
anti-glutamic acid decarboxylase antibodies
anti-glycine receptor antibody
Neurology
progressive encephalomyelitis with rigidity and myoclonus
thymoma
tumors
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Summary:Progressive encephalomyelitis with rigidity and myoclonus (PERM) is part of the variant type of the Stiff Person Syndrome (SPS) and is a rare neurological disease. We report here a patient with PERM who had thymoma and was positive for anti-glutamic acid decarboxylase (anti-GAD) antibodies. Her symptoms improved after treatment with hormones and gamma globulin. We also summarized the literature review of patients with PERM accompanied by tumors reported.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.01017