Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study

To measure ascorbic acid concentration in aqueous humor of patients with cataract after oral or intravenous vitamin C supplementation. Forty-two eyes of 42 patients with senile cataract who underwent uncomplicated cataract surgery were enrolled. Patients (n = 14 each) were administered oral vitamin...

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Bibliographic Details
Published in:BMC ophthalmology 2017-07, Vol.17 (1), p.121-121, Article 121
Main Authors: Hah, Young-Sool, Chung, Hye Jin, Sontakke, Sneha B, Chung, In-Young, Ju, Sunmi, Seo, Seong-Wook, Yoo, Ji-Myong, Kim, Seong-Jae
Format: Article
Language:English
Subjects:
Acids
Administration, Oral
Age
Analysis
Anterior chamber
Antioxidant
Antioxidants - administration & dosage
Antioxidants - pharmacokinetics
Aqueous humor
Aqueous Humor - chemistry
Ascorbic acid
Ascorbic Acid - administration & dosage
Ascorbic Acid - pharmacokinetics
Biomarkers - metabolism
Care and treatment
Cataract
Cataract - diet therapy
Cataract - metabolism
Cataract Extraction
Cataracts
Chromatography
Chromatography, High Pressure Liquid
Dietary supplements
Dosage and administration
Eye diseases
Female
Follow-Up Studies
Glaucoma
High performance liquid chromatography
Humans
Injections, Intravenous
Intravenous administration
Male
Measurement
Middle Aged
Ophthalmology
Oral administration
Physiological aspects
Pilot Projects
Plasma
Prospective Studies
Surgery
Variance analysis
Vitamin C
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Summary:To measure ascorbic acid concentration in aqueous humor of patients with cataract after oral or intravenous vitamin C supplementation. Forty-two eyes of 42 patients with senile cataract who underwent uncomplicated cataract surgery were enrolled. Patients (n = 14 each) were administered oral vitamin C (2 g), intravenous vitamin C (20 g) or no treatment (control group) on the day before surgery. Samples of aqueous humor (0.1 cm ) were obtained by anterior chamber aspiration at the beginning of surgery and stored at -80 °C. Ascorbic acid concentration in aqueous humor was measured by high-pressure liquid chromatography. The mean age at surgery was 62.5 years, with no difference among the three groups. The mean ± standard deviation concentrations of ascorbic acid in aqueous humor in the control and oral and intravenous vitamin C groups were 1347 ± 331 μmol/L, 1859 ± 408 μmol/L and 2387 ± 445 μmol/L, respectively. Ascorbic acid concentration was significantly lower in the control than in the oral (P 
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-017-0515-2