Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

ObjectivesTo investigate the association between exposure to potentially inappropriate medication (PIM) and poor prognosis of COVID-19 in older adults, controlling for comorbidity and sociodemographic factors.Design and settingNationwide retrospective cohort study based on the national registry of C...

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Bibliographic Details
Published in:BMJ open 2024-07, Vol.14 (7), p.e073367
Main Authors: Kim, Hyungmin, Hong, Song Hee
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anticholinergics
Benzodiazepines
Cohort analysis
Comorbidity
COVID-19
COVID-19 - epidemiology
COVID-19 - mortality
Critical care
Critical Care - statistics & numerical data
Dementia
Diabetes
Disease control
Epidemics
Fatalities
Female
Geriatric Medicine
health services for the aged
Humans
Hypertension
Immune system
Inappropriate Prescribing - statistics & numerical data
Infections
Insurance claims
Low income groups
Male
Medical prognosis
Middle Aged
Mortality
National health insurance
Nervous system
Older people
Original Research
Patients
Potentially Inappropriate Medication List - statistics & numerical data
Prognosis
public health
quality in health care
Registries
Regression analysis
Republic of Korea - epidemiology
Retrospective Studies
SARS-CoV-2
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Summary:ObjectivesTo investigate the association between exposure to potentially inappropriate medication (PIM) and poor prognosis of COVID-19 in older adults, controlling for comorbidity and sociodemographic factors.Design and settingNationwide retrospective cohort study based on the national registry of COVID-19 patients, established through the linkage of South Korea’s national insurance claims database with the Korea Disease Control and Prevention Agency registry of patients with COVID-19, up to 31 July 2020.ParticipantsA total of 2217 COVID-19 patients over 60 years of age who tested positive between 20 January 2020 and 4 June 2020. Exposure to PIM was defined based on any prescription record of PIM during the 30 days prior to the date of testing positive for COVID-19.Primary outcome measuresMortality and utilisation of critical care from the date of testing positive until the end of isolation.ResultsAmong the 2217 COVID-19 patients over 60 years of age, 604 were exposed to PIM prior to infection. In the matched cohort of 583 pairs, PIM-exposed individuals exhibited higher rates of mortality (19.7% vs 9.8%, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2023-073367