Does postoperative cognitive decline after coronary bypass affect quality of life?

ObjectiveThis study aimed to explore the influence of coronary artery bypass grafting (CABG) on both postoperative cognitive dysfunction and quality of life (QoL) and the association between the two patient-related outcomes.MethodsIn a prospective, observational cohort study, patients with elective,...

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Bibliographic Details
Published in:Open heart 2021-04, Vol.8 (1), p.e001569
Main Authors: Blokzijl, Fredrike, Keus, Frederik, Houterman, Saskia, Dieperink, Willem, van der Horst, Iwan C C, Reneman, Michiel F, Absalom, Anthony R, Mariani, Massimo A
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiac Surgery
Cognitive ability
coronary artery bypass
Coronary vessels
Delirium
healthcare
Heart surgery
outcome assessment
Patients
Quality of life
Questionnaires
Software
Stroke
Transient ischemic attack
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Summary:ObjectiveThis study aimed to explore the influence of coronary artery bypass grafting (CABG) on both postoperative cognitive dysfunction and quality of life (QoL) and the association between the two patient-related outcomes.MethodsIn a prospective, observational cohort study, patients with elective, isolated CABG were included. Cognitive function was assessed using the Cogstate computerised cognitive test battery preoperatively, 3 days and 6 months after surgery. QoL was measured preoperatively and at 6 months using the RAND-36 questionnaire including the Physical Component Score (PCS) and the Mental Component Score (MCS). Regression analysis, with adjustment for confounders, was used to evaluate the association between postoperative cognitive dysfunction and QoL.ResultsA total of 142 patients were included in the study. Evidence of persistent cognitive dysfunction was observed in 33% of patients after 6 months. At 6 months, the PCS had improved in 59% and decreased in 21% of patients, and the MCS increased in 49% and decreased in 29%. Postoperative cognitive changes were not associated with QoL scores.ConclusionsPostoperative cognitive dysfunction and decreased QoL are common 6 months after surgery, although cognitive function and QoL were found to have improved in many patients at 6 months of follow-up. Impaired cognitive function is not associated with impaired QoL at 6 months.Trial registration numberNCT03774342.
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2020-001569