New Role of the Serotonin as a Biomarker of Gut-Brain Interaction

Serotonin (5-hydroxytryptamine: 5-HT), a neurotransmitter that regulates mood in the brain and signaling in the gut, has receptors throughout the body that serve various functions, especially in the gut and brain. Selective serotonin reuptake inhibitors (SSRIs) are used to treat depression, but thei...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2024-10, Vol.14 (10), p.1280
Main Authors: Liu, Hong Nian, Nakamura, Masanao, Kawashima, Hiroki
Format: Article
Language:English
Subjects:
Anxiety
Biological markers
biomarker
Biomarkers
Brain
Complications and side effects
Crohn's disease
Depression, Mental
Development and progression
Diagnosis
Digestive system
Disorders
Dyspepsia
functional dyspepsia (FD)
Functionals
Gastrointestinal diseases
Gastrointestinal symptoms
Gastrointestinal tract
gut–brain interaction
Health aspects
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Irritable bowel syndrome
irritable bowel syndrome (IBS)
Kinases
Measurement
Medical innovations
Mental depression
mood
Motility
Neurodevelopmental disorders
Neurons
Pacemakers
Proteins
Psychiatric research
Remission (Medicine)
Review
Serotonin
Serotonin uptake inhibitors
Ulcerative colitis
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Description
Summary:Serotonin (5-hydroxytryptamine: 5-HT), a neurotransmitter that regulates mood in the brain and signaling in the gut, has receptors throughout the body that serve various functions, especially in the gut and brain. Selective serotonin reuptake inhibitors (SSRIs) are used to treat depression, but their efficacy is uncertain. Depression is often associated with early gastrointestinal symptoms. Gut disorders such as functional dyspepsia (FD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are linked to elevated serotonin levels. In this review, we would like to discuss the approach of using serotonin as a biomarker for gut-brain, and body-wide organ communication may lead to the development of preventive and innovative treatments for gut-brain disorders, offering improved visibility and therapeutic monitoring. It could also be used to gauge stress intensity for self-care and mental health improvement.
ISSN:2075-1729
2075-1729
DOI:10.3390/life14101280