Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish

Bisphenol F (BPF; 4,4'-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic eff...

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Bibliographic Details
Published in:Toxics (Basel) 2023-05, Vol.11 (6), p.477
Main Authors: Kim, Yeonhwa, Kim, Seong Soon, Park, Byeong Heon, Hwang, Kyu-Seok, Bae, Myung Ae, Cho, Sung-Hee, Kim, Suhyun, Park, Hae-Chul
Format: Article
Language:English
Subjects:
Bisphenol A
bisphenol F
Bisphenols
Chemical properties
Danio rerio
Degeneration
Edema
Embryos
Environmental aspects
Epoxy resins
Exposure
Health aspects
Larvae
Locomotion
Locomotor activity
Motor activity
motor neuron
Motor task performance
Myelination
neurochemicals
Neurosteroids
Neurotoxicity
Neurotoxicity syndromes
Oxidative stress
Physiological aspects
Report writing
Risk factors
Startle response
Testosterone
Zebra fish
Zebrafish
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Summary:Bisphenol F (BPF; 4,4'-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11060477