New Glycosides from the Fruits of Nicandra physaloides

Three new glycosides ( - ) and 15 known ones ( - ) were isolated and identified from the fruits of . The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds ( - ) were the first time isolated from the genus and they (except , , ) exhibited inhibitions...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-05, Vol.22 (5), p.828
Main Authors: Liu, Yan, Jiang, Hai-Bing, Xu, Zhen-Peng, Cheng, Yan-Gang, Lv, Shao-Wa, Yang, Bing-You, Guo, Hong-Wei, Kuang, Hai-Xue
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Chromatography, Gas
fat glycosides
Fruit - chemistry
Fruits
Glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Herbal medicine
Hydrocarbons
Hydrolysis
inflammation
Lipopolysaccharides
Macrophage Activation
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nicandra physaloides
Nitric Oxide - metabolism
NMR
Nuclear magnetic resonance
phenyl-glycosides
RAW 264.7
RAW 264.7 Cells
Solanaceae - chemistry
Spectra
Spectrometry, Mass, Electrospray Ionization
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Summary:Three new glycosides ( - ) and 15 known ones ( - ) were isolated and identified from the fruits of . The structures of these compounds were established by 1D and 2D NMR spectra and HR-ESI-MS. The compounds ( - ) were the first time isolated from the genus and they (except , , ) exhibited inhibitions on the NO release of LPS-induced RAW 264.7 cells with IC values from 26.9 to 47.5 μM.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22050828