Characterization of Histone Deacetylase Mechanisms in Cancer Development

Over decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of physiological processes. Histone deacetylases (...

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Bibliographic Details
Published in:Frontiers in oncology 2021-07, Vol.11, p.700947-700947
Main Authors: Hai, Rihan, He, Liuer, Shu, Guang, Yin, Gang
Format: Article
Language:English
Subjects:
cancer
epigenetics
histone deacetylases
Oncology
protein acetylation
tumorigenesis
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Summary:Over decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of physiological processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are pivotal epigenetic modulators that regulate dynamic processes in the acetylation of histones at lysine residues, thereby influencing transcription of oncogenes and tumour suppressor genes. Moreover, HDACs mediate the deacetylation process of many nonhistone proteins and thus orchestrate a host of pathological processes, such as tumour pathogenesis. In this review, we elucidate the functions of HDACs in cancer.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.700947