Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates

Sex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal bou...

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Bibliographic Details
Published in:eLife 2020-11, Vol.9
Main Authors: Shearn, Rylan, Wright, Alison E, Mousset, Sylvain, Régis, Corinne, Penel, Simon, Lemaitre, Jean-François, Douay, Guillaume, Crouau-Roy, Brigitte, Lecompte, Emilie, Marais, Gabriel Ab
Format: Article
Language:English
Subjects:
Animals
Evolution, Molecular
Evolutionary Biology
Female
lemurs
Life Sciences
Male
Polymorphism, Single Nucleotide
primates
recombination suppression
Sex Chromosomes
sexual dimorphism
sexually antagonistic mutations
Short Report
Species Specificity
Strepsirhini - genetics
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Summary:Sex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and monkeys) but not in strepsirrhines (lemurs and lorises). Here, we studied the PAB of seven species representing the main strepsirrhine lineages by sequencing a male and a female genome in each species and using sex differences in coverage to identify the PAB. We found that during primate evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines. Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We suggest that mutations with antagonistic effects between males and females have driven recombination suppression and PAB evolution in haplorrhines.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.63650