KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma

Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and inju...

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Published in:Frontiers in endocrinology (Lausanne) 2022-03, Vol.13, p.830130-830130
Main Authors: Lee, Bo-Ching, Kang, Victor Jing-Wei, Pan, Chien-Ting, Huang, Jia-Zheng, Lin, Yu-Li, Chang, Yi-Yao, Tsai, Cheng-Hsuan, Chou, Chia-Hung, Chen, Zheng-Wei, Liao, Che-Wei, Chiu, Yu-Wei, Wu, Vin-Cent, Hung, Chi-Sheng, Chang, Chin-Chen, Lin, Yen-Hung
Format: Article
Language:English
Subjects:
Adenoma - genetics
Adrenal Cortex Neoplasms - complications
Adrenal Cortex Neoplasms - genetics
Adrenal Cortex Neoplasms - surgery
Adrenocortical Adenoma - complications
Adrenocortical Adenoma - genetics
Adrenocortical Adenoma - surgery
Aldosterone
Aorta
aortic calcification
Calcinosis - genetics
Endocrinology
G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics
Humans
Hyperaldosteronism - complications
Hyperaldosteronism - genetics
hypertension
KCNJ5 somatic mutation
Mutation
primary aldosteronism
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Summary:Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status. We enrolled 179 APA patients who had undergone adrenalectomy from a prospectively maintained database, of whom 99 had KCNJ5 somatic mutations. Preoperative clinical, biochemical and imaging data of abdominal CT, including abdominal aortic calcification (AAC) score, aortic diameter and wall thickness at levels of superior (SMA) and inferior (IMA) mesenteric arteries were analyzed. After propensity score matching for age, sex, body mass index, triglycerides and low-density lipoprotein, there were 48 patients in each KCNJ5 (+) and KCNJ5 (-) group. Mutation carriers had a lower AAC score (217.3 ± 562.2 vs. 605.6 ± 1359.1, P=0.018), higher aortic wall thickness (SMA level: 2.2 ± 0.6 mm vs. 1.8 ± 0.6 mm, P=0.006; IMA level: 2.4 ± 0.6 mm vs. 1.8 ± 0.7 mm, P
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.830130