Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist

This review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that...

Full description

Saved in:
Bibliographic Details
Published in:Annals of cardiac anaesthesia 2010-09, Vol.13 (3), p.206-216
Main Authors: Hemmerling, Thomas, Zaouter, Cedrick, Geldner, Goetz, Nauheimer, Dirk
Format: Article
Language:English
Subjects:
Airway management
Anesthesiology
Cardiac surgery
Clinical medicine
Drug therapy
Neuromuscular blocking agents
Plasma
review
sugammadex
Surgery
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that binds a chemical complex with rocuronium and vecuronium, by which the neuromuscular blockade is quickly reversed. It is free of any clinical side-effects and doses of 2 mg/kg or more reliably reverse neuromuscular blockade within 5-15 min, depending on the depth of the neuromuscular blockade. Doses below 2 mg/kg should be avoided at any time because of the inherent risk of recurarization. Sugammadex should not replace good clinical practice - titration of neuromuscular blocking drugs to clinical needs and objective monitoring of neuromuscular blockade in the operating room or intensive care unit. Neuromuscular transmission should be determined in all patients before sugammadex is considered and 5 min after its administration to ensure that extubation is performed with normal neuromuscular transmission.
ISSN:0971-9784
0974-5181
DOI:10.4103/0971-9784.69052