Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI

Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting...

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Bibliographic Details
Published in:Case reports in hematology 2023-06, Vol.2023, p.5926340-4
Main Authors: Beck, Patrick J., Benfield, John, Morales, Joshua
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Antibodies
Anticoagulants
Anticoagulants (Medicine)
Aspirin
Blood
Blood clot
Cardioversion
Case Report
Clopidogrel
Coronary heart disease
Diabetes
Drug dosages
Glycoproteins
Health aspects
Hyperlipidemia
Hypertension
Lupus
Medical examination
Patients
Plasma
Thromboembolism
Thrombosis
Type 2 diabetes
Veins & arteries
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Summary:Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting of acute coronary syndrome (ACS). Here, we present the case of a 52-year-old man presenting with chest pain and diagnosed with an NSTEMI but also found with a prolonged baseline aPTT ultimately secondary to FXII deficiency. Here, we discuss the diagnostic work-up of an isolated prolonged aPTT to identify possible etiologies, such as FXII deficiency, and ultimately inform ACS management.
ISSN:2090-6560
2090-6579
DOI:10.1155/2023/5926340