Response to 5-Fluorouracil-Based Chemotherapy in a Patient with Metastatic Colonic-Type Adenocarcinoma Arising in a Primary Mediastinal Teratoma

Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To our knowledge...

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Bibliographic Details
Published in:Case reports in oncological medicine 2012-01, Vol.2012 (2012), p.1-4
Main Authors: Dechaphunkul, Arunee, Bigras, Gilbert, Sawyer, Michael
Format: Article
Language:English
Subjects:
Abdomen
Cancer therapies
Case Report
Colleges & universities
Family medical history
Histology
Medicine
Oncology
Patients
Surgery
Tumors
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Summary:Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To our knowledge, there were 3 cases of colonic-type adenocarcinoma arising in a primary teratoma have been reported to date. However, none of them received chemotherapy directed to transformed histology given localized disease at presentation. We, therefore, report here the first case of patient who achieved good response from chemotherapy directed to transformed histology, which confirms the importance of chemotherapy regimen used.
ISSN:2090-6706
2090-6714
DOI:10.1155/2012/729278