Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnor...

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Published in:International journal of ophthalmology 2024-10, Vol.17 (10), p.1869-1879
Main Authors: Chen, Li-Ming, Kang, Min, Wang, Jun-Yi, Xu, San-Hua, Chen, Cheng, Wei, Hong, Ling, Qian, He, Liang-Qi, Zou, Jie, Wang, Yi-Xin, Chen, Xu, Ying, Ping, Huang, Hui, Shao, Yi, Wu, Rui
Format: Article
Language:English
Subjects:
Clinical Research
connective tissue desease-related interstitial lung disease
microvessel density
ocular surface
optical coherence tomography angiography
retina
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Summary:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnormal eyes. For a retrospective case-control study, a total of 16 patients (32 eyes) diagnosed with CTD-ILD were selected as the ILD group. The 16 healthy volunteers with 32 eyes, matched in terms of age and sex with the patients, were recruited as control group. The macular retina's superficial retinal layer (SRL) and deep retinal layer (DRL) were examined and scanned using OCTA in each individual eye. The densities of retinal microvascular (MIR), macrovascular (MAR), and total microvascular (TMI) were calculated and compared. Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods: central annuli segmentation method (C1-C6), hemispheric segmentation method [uperior right (SR), superior left (SL), inferior left (IL), and inferior right (IR)], and Early Treatment Diabetic Retinopathy Study (ETDRS) methods [superior (S), inferior (I), left (L), and right (R)]. The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis. The OCTA data demonstrated a statistically significant difference (
ISSN:2222-3959
2227-4898
DOI:10.18240/ijo.2024.10.14