Single Cell Atlas: a single-cell multi-omics human cell encyclopedia

Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spa...

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Bibliographic Details
Published in:Genome Biology 2024-04, Vol.25 (1), p.104-104, Article 104
Main Authors: Pan, Lu, Parini, Paolo, Tremmel, Roman, Loscalzo, Joseph, Lauschke, Volker M, Maron, Bradley A, Paci, Paola, Ernberg, Ingemar, Tan, Nguan Soon, Liao, Zehuan, Yin, Weiyao, Rengarajan, Sundararaman, Li, Xuexin
Format: Article
Language:English
Subjects:
adults
Biological analysis
Cells
complement
data collection
Fetuses
Flow cytometry
Gene expression
genome
Human database
humans
Internet
Lymphocytes
medicine
Multi-omics
multiomics
Single Cell Atlas
Single-cell omics
Single-cell RNA-sequencing
Spatial transcriptomics
Transcriptomics
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Summary:Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org ), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.
ISSN:1474-760X
1474-7596
1474-760X
DOI:10.1186/s13059-024-03246-2