Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population

The present study was designed to investigate the association between rs8177374 polymorphism and malaria symptoms due to exposure of Plasmodium vivax and Plasmodium falciparum. A total of 454 samples were included in the study (228 malaria patients and 226 healthy individuals). Malaria patients, div...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2017-07, Vol.21 (4), p.418-423
Main Authors: Rani, Asima, Nawaz, Syed Kashif, Irfan, Shazia, Arshad, Muhammad, Bashir, Razia, Shaheen, Najma
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Female
Gene Frequency
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Genotype
Humans
INFECTIOUS DISEASES
MAL
Malaria
Malaria, Falciparum - genetics
Malaria, Vivax - genetics
Male
Membrane Glycoproteins - genetics
Membrane Glycoproteins - physiology
Original
Pakistan
Pakistani population
Plasmodium
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Receptors, Interleukin-1 - genetics
Receptors, Interleukin-1 - physiology
rs8177374
Severity of Illness Index
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Summary:The present study was designed to investigate the association between rs8177374 polymorphism and malaria symptoms due to exposure of Plasmodium vivax and Plasmodium falciparum. A total of 454 samples were included in the study (228 malaria patients and 226 healthy individuals). Malaria patients, divided into P. vivax and P. falciparum groups on the basis of the causative species of Plasmodium, were categorized into mild and severe on the basis of clinical outcomes according to WHO criteria. Healthy individuals were used as controls. Allele specific PCR based strategy was used for the identification of rs8177374 SNP. MyD88-adaptor-like gene polymorphism was associated with susceptibility to malaria (p
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1016/j.bjid.2017.04.002