Comparison of the efficacy of curcumin and its nano formulation on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in Wistar rats

Insulin resistance is a primary feature of type 2 diabetes. This study compared the effects of curcumin and its nanoformulation on insulin resistance, fasting blood sugar, liver function, GLUT4, lipid profile, and oxidative stress in the liver and pancreas in a diabetic model. Thirty male Wistar rat...

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Bibliographic Details
Published in:Heliyon 2024-12, Vol.10 (24), p.e41043, Article e41043
Main Authors: Hamed, Amany M., Elbahy, Dalia A., Ahmed, Ahmed RH, Thabet, Shymaa A., Refaei, Rasha Abdeen, Ragab, Islam, Elmahdy, Safaa Mohammed, Osman, Ahmed S., Abouelella, Azza MA
Format: Article
Language:English
Subjects:
Antihyperglycemic
Antihyperlipidemic
Insulin resistance
Liver steatosis
Nano-curcumin
Type 2 diabetes
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Summary:Insulin resistance is a primary feature of type 2 diabetes. This study compared the effects of curcumin and its nanoformulation on insulin resistance, fasting blood sugar, liver function, GLUT4, lipid profile, and oxidative stress in the liver and pancreas in a diabetic model. Thirty male Wistar rats were divided into five groups: a control group, a diabetic group, a diabetic group treated with metformin (40 mg/kg), a diabetic group treated with curcumin (100 mg/kg), and a diabetic group treated with curcumin NPs (100 mg/kg). Diabetes was induced by injecting dexamethasone daily for 14 days. Treatment with curcumin and curcumin NPs was administered by gavage for 14 days. Body weight and fasting blood sugar levels were measured on days 1, 14, and 28. The metformin, curcumin, and curcumin NPs groups showed significantly greater body weight gain than the untreated diabetic group (P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e41043