Advances in the Application of Transition-Metal Composite Nanozymes in the Field of Biomedicine

Due to the limitation that natural peroxidase enzymes can only function in relatively mild environments, nanozymes have expanded the application of enzymology in the biological field by dint of their ability to maintain catalytic oxidative activity in relatively harsh environments. At the same time,...

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Published in:Biosensors (Basel) 2024-01, Vol.14 (1), p.40
Main Authors: Wang, Huixin, Cheng, Chunfang, Zhao, Jingyu, Han, Fangqin, Zhao, Guanhui, Zhang, Yong, Wang, Yaoguang
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Antigens
Biomedical materials
Biosensors
Breast cancer
Chemical properties
Composite materials
composites
Dextrose
Disease
Enzymatic activity
Enzymes
Enzymology
Glucose
Gold
Harsh environments
Health aspects
Hydrogen peroxide
Medical diagnosis
Metal Nanoparticles
Metals
Methylene blue
MicroRNAs
mimicking peroxidase
Mimicry
Nanomaterials
Nanoparticles
Nanostructures
Nanotechnology
nanozymes
Noble metals
Oxidation
Peroxidase
Peroxidases
Platinum
Prostate
Silver
Structure
Transition Elements
transition metal
Transition metal compounds
Transition metals
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cited_by cdi_FETCH-LOGICAL-c490t-532794b6af97f19a1aa0ef2832fd6c4f87eeb87194c9c885b09dd84b49c16ce23
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Zhang, Yong
Wang, Yaoguang
description Due to the limitation that natural peroxidase enzymes can only function in relatively mild environments, nanozymes have expanded the application of enzymology in the biological field by dint of their ability to maintain catalytic oxidative activity in relatively harsh environments. At the same time, the development of new and highly efficient composite nanozymes has been a challenge due to the limitations of monometallic particles in applications and the inherently poor enzyme-mimetic activity of composite nanozymes. The inherent enzyme-mimicking activity is due to Au, Ag, and Pt, along with other transition metals. Moreover, the nanomaterials exhibit excellent enzyme-mimicking activity when composited with other materials. Therefore, this paper focuses on composite nanozymes with simulated peroxidase activity that have been prepared using noble metals such as Au, Ag, and Pt and other transition metal nanoparticles in recent years. Their simulated enzymatic activity is utilized for biomedical applications such as glucose detection, cancer cell detection and tumor treatment, and antibacterial applications.
doi_str_mv 10.3390/bios14010040
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subjects Anti-Bacterial Agents
Antigens
Biomedical materials
Biosensors
Breast cancer
Chemical properties
Composite materials
composites
Dextrose
Disease
Enzymatic activity
Enzymes
Enzymology
Glucose
Gold
Harsh environments
Health aspects
Hydrogen peroxide
Medical diagnosis
Metal Nanoparticles
Metals
Methylene blue
MicroRNAs
mimicking peroxidase
Mimicry
Nanomaterials
Nanoparticles
Nanostructures
Nanotechnology
nanozymes
Noble metals
Oxidation
Peroxidase
Peroxidases
Platinum
Prostate
Silver
Structure
Transition Elements
transition metal
Transition metal compounds
Transition metals
title Advances in the Application of Transition-Metal Composite Nanozymes in the Field of Biomedicine
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