Air pollution and plasma amyloid beta in a cohort of older adults: Evidence from the Ginkgo Evaluation of Memory study

• Published in: Environment international 2023-02, Vol.172, p.107800-107800, Article 107800
• Main Authors: Hajat, Anjum, Park, Christina, Adam, Claire, Fitzpatrick, Annette L., Ilango, Sindana D., Leary, Cindy, Libby, Tanya, Lopez, Oscar, Semmens, Erin O., Kaufman, Joel D.
• Format: Article
• Language: English
• Subjects: Aged; Aging; Air Pollutants - adverse effects; Air Pollutants - analysis; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; Alzheimer’s disease; Amyloid beta; Amyloid beta-Peptides - analysis; Biomarkers; Cross-Sectional Studies; Dementia; Environmental Exposure - adverse effects; Environmental Exposure - analysis; Ginkgo biloba; Humans; Nitrogen Dioxide - adverse effects; Nitrogen Dioxide - analysis; Particulate Matter - adverse effects; Particulate Matter - analysis
• ISSN: 0160-4120; 1873-6750
• DOI: 10.1016/j.envint.2023.107800

•Mechanisms of air pollution and Alzheimer’s disease and related dementias not clear.•Association between air pollution and plasma amyloid beta has not been studied.•Positive association between air pollution and amyloid beta.•Air pollution is modifiable target for dementia prevention. Air pollution has been linked to Alzheimer’s disease and related dementias (ADRD), but the mechanisms connecting air pollution to ADRD have not been firmly established. Air pollution may cause oxidative stress and neuroinflammation and contribute to the deposition of amyloid beta (Aβ) in the brain. We examined the association between fine particulate matter