Decoding Chiari Malformation and Syringomyelia: From Epidemiology and Genetics to Advanced Diagnosis and Management Strategies

Chiari Malformation and Syringomyelia are neurosurgical entities that have been the subject of extensive research and clinical interest. Globally prevalent, these disorders vary demographically and have witnessed evolving temporal trends. Chiari Malformation impacts the normal cerebrospinal fluid fl...

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Bibliographic Details
Published in:Brain sciences 2023-11, Vol.13 (12), p.1658
Main Authors: Toader, Corneliu, Ples, Horia, Covache-Busuioc, Razvan-Adrian, Costin, Horia Petre, Bratu, Bogdan-Gabriel, Dumitrascu, David-Ioan, Glavan, Luca Andrei, Ciurea, Alexandru Vlad
Format: Article
Language:English
Subjects:
Anencephaly
Brain
Brain research
Care and treatment
cerebral malformation
Cerebrospinal fluid
Chiari 1
Chiari 2
Congenital defects
Diagnosis
Epidemiology
Fluid flow
Forecasts and trends
Health aspects
Magnetic resonance imaging
Neural tube defects
Neuroimaging
Neurophysiology
Neurosurgery
Patients
Phenotypes
Quality of life
Spinal cord
Surgery
Surgical outcomes
Syringomyelia
syrinx pathologies
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Summary:Chiari Malformation and Syringomyelia are neurosurgical entities that have been the subject of extensive research and clinical interest. Globally prevalent, these disorders vary demographically and have witnessed evolving temporal trends. Chiari Malformation impacts the normal cerebrospinal fluid flow, consequently affecting overall health. Key observations from canine studies offer pivotal insights into the pathogenesis of Syringomyelia and its extrapolation to human manifestations. Genetics plays a pivotal role; contemporary knowledge identifies specific genes, illuminating avenues for future exploration. Clinically, these disorders present distinct phenotypes. Diagnostically, while traditional methods have stood the test of time, innovative neurophysiological techniques are revolutionizing early detection and management. Neuroradiology, a cornerstone in diagnosis, follows defined criteria. Advanced imaging techniques are amplifying diagnostic precision. In therapeutic realms, surgery remains primary. For Chiari 1 Malformation, surgical outcomes vary based on the presence of Syringomyelia. Isolated Syringomyelia demands a unique surgical approach, the effectiveness of which is continually being optimized. Post-operative long-term prognosis and quality of life measures are crucial in assessing intervention success. In conclusion, this review amalgamates existing knowledge, paving the way for future research and enhanced clinical strategies in the management of Chiari Malformation and Syringomyelia.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13121658